A Broad-Based Characterization of a Cell-Penetrating, Single Domain Camelid Bi-Specific Antibody Monomer That Targets STAT3 and KRAS Dependent Cancers

STAT3 and KRAS regulate cell proliferation, survival, apoptosis, cell migration, and angiogenesis. Aberrant expression of STAT3 and mutant active forms of KRAS have been well-established in the induction and maintenance of multiple cancers. STAT3 and KRAS mutant proteins have been considered anti-ca...

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Detalles Bibliográficos
Autores principales: Singh, Sunanda, Murillo, Genoveva, Richner, Justin, Singh, Samara P., Berleth, Erica, Kumar, Vijay, Mehta, Rajendra, Ramiya, Vijay, Parihar, Ashutosh S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323098/
https://www.ncbi.nlm.nih.gov/pubmed/35886918
http://dx.doi.org/10.3390/ijms23147565

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