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A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective
Cell regenerative therapy is a modern solution for difficult-to-heal wounds. Keratinocytes, the most common cell type in the skin, are difficult to obtain without the creation of another wound. Stem cell differentiation towards keratinocytes is a challenging process, and it is difficult to reproduce...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323141/ https://www.ncbi.nlm.nih.gov/pubmed/35887279 http://dx.doi.org/10.3390/ijms23147934 |
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author | El-Serafi, Ahmed T. El-Serafi, Ibrahim Steinvall, Ingrid Sjöberg, Folke Elmasry, Moustafa |
author_facet | El-Serafi, Ahmed T. El-Serafi, Ibrahim Steinvall, Ingrid Sjöberg, Folke Elmasry, Moustafa |
author_sort | El-Serafi, Ahmed T. |
collection | PubMed |
description | Cell regenerative therapy is a modern solution for difficult-to-heal wounds. Keratinocytes, the most common cell type in the skin, are difficult to obtain without the creation of another wound. Stem cell differentiation towards keratinocytes is a challenging process, and it is difficult to reproduce in chemically defined media. Nevertheless, a co-culture of keratinocytes with stem cells usually achieves efficient differentiation. This systematic review aims to identify the secretions of normal human keratinocytes reported in the literature and correlate them with the differentiation process. An online search revealed 338 references, of which 100 met the selection criteria. A total of 80 different keratinocyte secretions were reported, which can be grouped mainly into cytokines, growth factors, and antimicrobial peptides. The growth-factor group mostly affects stem cell differentiation into keratinocytes, especially epidermal growth factor and members of the transforming growth factor family. Nevertheless, the reported secretions reflected the nature of the involved studies, as most of them focused on keratinocyte interaction with inflammation. This review highlights the secretory function of keratinocytes, as well as the need for intense investigation to characterize these secretions and evaluate their regenerative capacities. |
format | Online Article Text |
id | pubmed-9323141 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93231412022-07-27 A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective El-Serafi, Ahmed T. El-Serafi, Ibrahim Steinvall, Ingrid Sjöberg, Folke Elmasry, Moustafa Int J Mol Sci Review Cell regenerative therapy is a modern solution for difficult-to-heal wounds. Keratinocytes, the most common cell type in the skin, are difficult to obtain without the creation of another wound. Stem cell differentiation towards keratinocytes is a challenging process, and it is difficult to reproduce in chemically defined media. Nevertheless, a co-culture of keratinocytes with stem cells usually achieves efficient differentiation. This systematic review aims to identify the secretions of normal human keratinocytes reported in the literature and correlate them with the differentiation process. An online search revealed 338 references, of which 100 met the selection criteria. A total of 80 different keratinocyte secretions were reported, which can be grouped mainly into cytokines, growth factors, and antimicrobial peptides. The growth-factor group mostly affects stem cell differentiation into keratinocytes, especially epidermal growth factor and members of the transforming growth factor family. Nevertheless, the reported secretions reflected the nature of the involved studies, as most of them focused on keratinocyte interaction with inflammation. This review highlights the secretory function of keratinocytes, as well as the need for intense investigation to characterize these secretions and evaluate their regenerative capacities. MDPI 2022-07-19 /pmc/articles/PMC9323141/ /pubmed/35887279 http://dx.doi.org/10.3390/ijms23147934 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review El-Serafi, Ahmed T. El-Serafi, Ibrahim Steinvall, Ingrid Sjöberg, Folke Elmasry, Moustafa A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective |
title | A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective |
title_full | A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective |
title_fullStr | A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective |
title_full_unstemmed | A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective |
title_short | A Systematic Review of Keratinocyte Secretions: A Regenerative Perspective |
title_sort | systematic review of keratinocyte secretions: a regenerative perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323141/ https://www.ncbi.nlm.nih.gov/pubmed/35887279 http://dx.doi.org/10.3390/ijms23147934 |
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