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Nucleosome-Omics: A Perspective on the Epigenetic Code and 3D Genome Landscape

Genetic information is loaded on chromatin, which involves DNA sequence arrangement and the epigenetic landscape. The epigenetic information including DNA methylation, nucleosome positioning, histone modification, 3D chromatin conformation, and so on, has a crucial impact on gene transcriptional reg...

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Autores principales: Kong, Siyuan, Lu, Yuhui, Tan, Shuhao, Li, Rongrong, Gao, Yan, Li, Kui, Zhang, Yubo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323251/
https://www.ncbi.nlm.nih.gov/pubmed/35885897
http://dx.doi.org/10.3390/genes13071114
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author Kong, Siyuan
Lu, Yuhui
Tan, Shuhao
Li, Rongrong
Gao, Yan
Li, Kui
Zhang, Yubo
author_facet Kong, Siyuan
Lu, Yuhui
Tan, Shuhao
Li, Rongrong
Gao, Yan
Li, Kui
Zhang, Yubo
author_sort Kong, Siyuan
collection PubMed
description Genetic information is loaded on chromatin, which involves DNA sequence arrangement and the epigenetic landscape. The epigenetic information including DNA methylation, nucleosome positioning, histone modification, 3D chromatin conformation, and so on, has a crucial impact on gene transcriptional regulation. Out of them, nucleosomes, as basal chromatin structural units, play an important central role in epigenetic code. With the discovery of nucleosomes, various nucleosome-level technologies have been developed and applied, pushing epigenetics to a new climax. As the underlying methodology, next-generation sequencing technology has emerged and allowed scientists to understand the epigenetic landscape at a genome-wide level. Combining with NGS, nucleosome-omics (or nucleosomics) provides a fresh perspective on the epigenetic code and 3D genome landscape. Here, we summarized and discussed research progress in technology development and application of nucleosome-omics. We foresee the future directions of epigenetic development at the nucleosome level.
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spelling pubmed-93232512022-07-27 Nucleosome-Omics: A Perspective on the Epigenetic Code and 3D Genome Landscape Kong, Siyuan Lu, Yuhui Tan, Shuhao Li, Rongrong Gao, Yan Li, Kui Zhang, Yubo Genes (Basel) Review Genetic information is loaded on chromatin, which involves DNA sequence arrangement and the epigenetic landscape. The epigenetic information including DNA methylation, nucleosome positioning, histone modification, 3D chromatin conformation, and so on, has a crucial impact on gene transcriptional regulation. Out of them, nucleosomes, as basal chromatin structural units, play an important central role in epigenetic code. With the discovery of nucleosomes, various nucleosome-level technologies have been developed and applied, pushing epigenetics to a new climax. As the underlying methodology, next-generation sequencing technology has emerged and allowed scientists to understand the epigenetic landscape at a genome-wide level. Combining with NGS, nucleosome-omics (or nucleosomics) provides a fresh perspective on the epigenetic code and 3D genome landscape. Here, we summarized and discussed research progress in technology development and application of nucleosome-omics. We foresee the future directions of epigenetic development at the nucleosome level. MDPI 2022-06-22 /pmc/articles/PMC9323251/ /pubmed/35885897 http://dx.doi.org/10.3390/genes13071114 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kong, Siyuan
Lu, Yuhui
Tan, Shuhao
Li, Rongrong
Gao, Yan
Li, Kui
Zhang, Yubo
Nucleosome-Omics: A Perspective on the Epigenetic Code and 3D Genome Landscape
title Nucleosome-Omics: A Perspective on the Epigenetic Code and 3D Genome Landscape
title_full Nucleosome-Omics: A Perspective on the Epigenetic Code and 3D Genome Landscape
title_fullStr Nucleosome-Omics: A Perspective on the Epigenetic Code and 3D Genome Landscape
title_full_unstemmed Nucleosome-Omics: A Perspective on the Epigenetic Code and 3D Genome Landscape
title_short Nucleosome-Omics: A Perspective on the Epigenetic Code and 3D Genome Landscape
title_sort nucleosome-omics: a perspective on the epigenetic code and 3d genome landscape
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323251/
https://www.ncbi.nlm.nih.gov/pubmed/35885897
http://dx.doi.org/10.3390/genes13071114
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