Cargando…

Associations between Biomarkers of Complement Activation, Galactose-Deficient IgA1 Antibody and the Updated Oxford Pathology Classification of IgA Nephropathy

Our prior study indicates a close relationship between alternative complement pathway activation, galactose-deficient IgA1 (Gd-IgA1) concentration and clinical severity of IgA nephropathy (IgAN). Nonetheless, the relationship between complement factors and the updated Oxford classification of IgAN r...

Descripción completa

Detalles Bibliográficos
Autores principales: Juan, Yun-Ting, Chiang, Wen-Chih, Lin, Wei-Chou, Yang, Cheng-Wen, Chou, San-Fang, Hung, Ruo-Wei, Chiu, Yen-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323307/
https://www.ncbi.nlm.nih.gov/pubmed/35887995
http://dx.doi.org/10.3390/jcm11144231
_version_ 1784756518290194432
author Juan, Yun-Ting
Chiang, Wen-Chih
Lin, Wei-Chou
Yang, Cheng-Wen
Chou, San-Fang
Hung, Ruo-Wei
Chiu, Yen-Ling
author_facet Juan, Yun-Ting
Chiang, Wen-Chih
Lin, Wei-Chou
Yang, Cheng-Wen
Chou, San-Fang
Hung, Ruo-Wei
Chiu, Yen-Ling
author_sort Juan, Yun-Ting
collection PubMed
description Our prior study indicates a close relationship between alternative complement pathway activation, galactose-deficient IgA1 (Gd-IgA1) concentration and clinical severity of IgA nephropathy (IgAN). Nonetheless, the relationship between complement factors and the updated Oxford classification of IgAN remains unclear. This study enrolled eighty-four previously untreated, biopsy-diagnosed IgAN patients. The clinical and laboratory findings were collected at the time of biopsy. Plasma levels of complement factor C5a, factor Ba and Gd-IgA1 were measured and analyzed. It was found that the levels of proteinuria positively correlated with the updated Oxford classification of mesangial hypercellularity (M), endocapillary hypercellularity (E), tubular atrophy/interstitial fibrosis (T) and crescents (C). In addition, plasma Gd-IgA1 titer was significantly elevated in IgAN patients with tubular atrophy/interstitial fibrosis (T). In separate multivariable logistic regression models, both Gd-IgA1 and factor Ba independently predict higher T scores. The results indicate that both the levels of Gd-IgA1 antibody and biomarkers of the alternative complement pathway activation reflect the Oxford classification of IgAN. Whether these biomarkers can be used to guide therapeutic decisions requires further study.
format Online
Article
Text
id pubmed-9323307
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93233072022-07-27 Associations between Biomarkers of Complement Activation, Galactose-Deficient IgA1 Antibody and the Updated Oxford Pathology Classification of IgA Nephropathy Juan, Yun-Ting Chiang, Wen-Chih Lin, Wei-Chou Yang, Cheng-Wen Chou, San-Fang Hung, Ruo-Wei Chiu, Yen-Ling J Clin Med Article Our prior study indicates a close relationship between alternative complement pathway activation, galactose-deficient IgA1 (Gd-IgA1) concentration and clinical severity of IgA nephropathy (IgAN). Nonetheless, the relationship between complement factors and the updated Oxford classification of IgAN remains unclear. This study enrolled eighty-four previously untreated, biopsy-diagnosed IgAN patients. The clinical and laboratory findings were collected at the time of biopsy. Plasma levels of complement factor C5a, factor Ba and Gd-IgA1 were measured and analyzed. It was found that the levels of proteinuria positively correlated with the updated Oxford classification of mesangial hypercellularity (M), endocapillary hypercellularity (E), tubular atrophy/interstitial fibrosis (T) and crescents (C). In addition, plasma Gd-IgA1 titer was significantly elevated in IgAN patients with tubular atrophy/interstitial fibrosis (T). In separate multivariable logistic regression models, both Gd-IgA1 and factor Ba independently predict higher T scores. The results indicate that both the levels of Gd-IgA1 antibody and biomarkers of the alternative complement pathway activation reflect the Oxford classification of IgAN. Whether these biomarkers can be used to guide therapeutic decisions requires further study. MDPI 2022-07-21 /pmc/articles/PMC9323307/ /pubmed/35887995 http://dx.doi.org/10.3390/jcm11144231 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Juan, Yun-Ting
Chiang, Wen-Chih
Lin, Wei-Chou
Yang, Cheng-Wen
Chou, San-Fang
Hung, Ruo-Wei
Chiu, Yen-Ling
Associations between Biomarkers of Complement Activation, Galactose-Deficient IgA1 Antibody and the Updated Oxford Pathology Classification of IgA Nephropathy
title Associations between Biomarkers of Complement Activation, Galactose-Deficient IgA1 Antibody and the Updated Oxford Pathology Classification of IgA Nephropathy
title_full Associations between Biomarkers of Complement Activation, Galactose-Deficient IgA1 Antibody and the Updated Oxford Pathology Classification of IgA Nephropathy
title_fullStr Associations between Biomarkers of Complement Activation, Galactose-Deficient IgA1 Antibody and the Updated Oxford Pathology Classification of IgA Nephropathy
title_full_unstemmed Associations between Biomarkers of Complement Activation, Galactose-Deficient IgA1 Antibody and the Updated Oxford Pathology Classification of IgA Nephropathy
title_short Associations between Biomarkers of Complement Activation, Galactose-Deficient IgA1 Antibody and the Updated Oxford Pathology Classification of IgA Nephropathy
title_sort associations between biomarkers of complement activation, galactose-deficient iga1 antibody and the updated oxford pathology classification of iga nephropathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323307/
https://www.ncbi.nlm.nih.gov/pubmed/35887995
http://dx.doi.org/10.3390/jcm11144231
work_keys_str_mv AT juanyunting associationsbetweenbiomarkersofcomplementactivationgalactosedeficientiga1antibodyandtheupdatedoxfordpathologyclassificationofiganephropathy
AT chiangwenchih associationsbetweenbiomarkersofcomplementactivationgalactosedeficientiga1antibodyandtheupdatedoxfordpathologyclassificationofiganephropathy
AT linweichou associationsbetweenbiomarkersofcomplementactivationgalactosedeficientiga1antibodyandtheupdatedoxfordpathologyclassificationofiganephropathy
AT yangchengwen associationsbetweenbiomarkersofcomplementactivationgalactosedeficientiga1antibodyandtheupdatedoxfordpathologyclassificationofiganephropathy
AT chousanfang associationsbetweenbiomarkersofcomplementactivationgalactosedeficientiga1antibodyandtheupdatedoxfordpathologyclassificationofiganephropathy
AT hungruowei associationsbetweenbiomarkersofcomplementactivationgalactosedeficientiga1antibodyandtheupdatedoxfordpathologyclassificationofiganephropathy
AT chiuyenling associationsbetweenbiomarkersofcomplementactivationgalactosedeficientiga1antibodyandtheupdatedoxfordpathologyclassificationofiganephropathy