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Early Gβγ-GRK2 Inhibition Ameliorates Osteoarthritis Development by Simultaneous Anti-Inflammatory and Chondroprotective Effects

The G-protein-coupled receptor kinase 2 (GRK2) is an important regulator of inflammation and pathological macrophage phenotype in a variety of diseases. We hypothesize that Gβγ-GRK2 signaling promotes the early inflammatory response and chondrocyte loss in osteoarthritis (OA). Using the destabilizat...

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Detalles Bibliográficos
Autores principales:	Karuppagounder, Vengadeshprabhu, Pinamont, William, Yoshioka, Natalie, Elbarbary, Reyad, Kamal, Fadia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323311/ https://www.ncbi.nlm.nih.gov/pubmed/35887281 http://dx.doi.org/10.3390/ijms23147933

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