A Ruthenium(II) Polypyridyl Complex Disrupts Actin Cytoskeleton Assembly and Blocks Cytokinesis

The dinuclear Ru(II) complex [(Ru(phen)(2))(2)(tpphz)](4+) (phen=1,10‐phenanthroline, tpphz=tetrapyridophenazine) “RuRuPhen” blocks the transformation of G‐actin monomers to F‐actin filaments with no disassembly of pre‐formed F‐actin. Molecular docking studies indicate multiple RuRuPhen molecules bi...

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Detalles Bibliográficos
Autores principales: Gill, Martin R., Jarman, Paul J., Hearnden, Vanessa, Fairbanks, Simon D, Bassetto, Marcella, Maib, Hannes, Palmer, John, Ayscough, Kathryn R., Thomas, Jim A., Smythe, Carl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323417/
https://www.ncbi.nlm.nih.gov/pubmed/35416386
http://dx.doi.org/10.1002/anie.202117449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323417/
https://www.ncbi.nlm.nih.gov/pubmed/35416386
http://dx.doi.org/10.1002/anie.202117449

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