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Structure, function and druggability of the African trypanosome flagellum
African trypanosomes are early branching protists that cause human and animal diseases, termed trypanosomiases. They have been under intensive study for more than 100 years and have contributed significantly to our understanding of eukaryotic biology. The combination of conserved and parasite‐specif...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323424/ https://www.ncbi.nlm.nih.gov/pubmed/35616248 http://dx.doi.org/10.1002/jcp.30778 |
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author | Sáez Conde, Julia Dean, Samuel |
author_facet | Sáez Conde, Julia Dean, Samuel |
author_sort | Sáez Conde, Julia |
collection | PubMed |
description | African trypanosomes are early branching protists that cause human and animal diseases, termed trypanosomiases. They have been under intensive study for more than 100 years and have contributed significantly to our understanding of eukaryotic biology. The combination of conserved and parasite‐specific features mean that their flagellum has gained particular attention. Here, we discuss the different structural features of the flagellum and their role in transmission and virulence. We highlight the possibilities of targeting flagellar function to cure trypanosome infections and help in the fight to eliminate trypanosomiases. |
format | Online Article Text |
id | pubmed-9323424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93234242022-07-30 Structure, function and druggability of the African trypanosome flagellum Sáez Conde, Julia Dean, Samuel J Cell Physiol Review Articles African trypanosomes are early branching protists that cause human and animal diseases, termed trypanosomiases. They have been under intensive study for more than 100 years and have contributed significantly to our understanding of eukaryotic biology. The combination of conserved and parasite‐specific features mean that their flagellum has gained particular attention. Here, we discuss the different structural features of the flagellum and their role in transmission and virulence. We highlight the possibilities of targeting flagellar function to cure trypanosome infections and help in the fight to eliminate trypanosomiases. John Wiley and Sons Inc. 2022-05-26 2022-06 /pmc/articles/PMC9323424/ /pubmed/35616248 http://dx.doi.org/10.1002/jcp.30778 Text en © 2022 The Authors. Journal of Cellular Physiology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Sáez Conde, Julia Dean, Samuel Structure, function and druggability of the African trypanosome flagellum |
title | Structure, function and druggability of the African trypanosome flagellum |
title_full | Structure, function and druggability of the African trypanosome flagellum |
title_fullStr | Structure, function and druggability of the African trypanosome flagellum |
title_full_unstemmed | Structure, function and druggability of the African trypanosome flagellum |
title_short | Structure, function and druggability of the African trypanosome flagellum |
title_sort | structure, function and druggability of the african trypanosome flagellum |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323424/ https://www.ncbi.nlm.nih.gov/pubmed/35616248 http://dx.doi.org/10.1002/jcp.30778 |
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