Cargando…

Structure, function and druggability of the African trypanosome flagellum

African trypanosomes are early branching protists that cause human and animal diseases, termed trypanosomiases. They have been under intensive study for more than 100 years and have contributed significantly to our understanding of eukaryotic biology. The combination of conserved and parasite‐specif...

Descripción completa

Detalles Bibliográficos
Autores principales: Sáez Conde, Julia, Dean, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323424/
https://www.ncbi.nlm.nih.gov/pubmed/35616248
http://dx.doi.org/10.1002/jcp.30778
_version_ 1784756547057876992
author Sáez Conde, Julia
Dean, Samuel
author_facet Sáez Conde, Julia
Dean, Samuel
author_sort Sáez Conde, Julia
collection PubMed
description African trypanosomes are early branching protists that cause human and animal diseases, termed trypanosomiases. They have been under intensive study for more than 100 years and have contributed significantly to our understanding of eukaryotic biology. The combination of conserved and parasite‐specific features mean that their flagellum has gained particular attention. Here, we discuss the different structural features of the flagellum and their role in transmission and virulence. We highlight the possibilities of targeting flagellar function to cure trypanosome infections and help in the fight to eliminate trypanosomiases.
format Online
Article
Text
id pubmed-9323424
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-93234242022-07-30 Structure, function and druggability of the African trypanosome flagellum Sáez Conde, Julia Dean, Samuel J Cell Physiol Review Articles African trypanosomes are early branching protists that cause human and animal diseases, termed trypanosomiases. They have been under intensive study for more than 100 years and have contributed significantly to our understanding of eukaryotic biology. The combination of conserved and parasite‐specific features mean that their flagellum has gained particular attention. Here, we discuss the different structural features of the flagellum and their role in transmission and virulence. We highlight the possibilities of targeting flagellar function to cure trypanosome infections and help in the fight to eliminate trypanosomiases. John Wiley and Sons Inc. 2022-05-26 2022-06 /pmc/articles/PMC9323424/ /pubmed/35616248 http://dx.doi.org/10.1002/jcp.30778 Text en © 2022 The Authors. Journal of Cellular Physiology published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
Sáez Conde, Julia
Dean, Samuel
Structure, function and druggability of the African trypanosome flagellum
title Structure, function and druggability of the African trypanosome flagellum
title_full Structure, function and druggability of the African trypanosome flagellum
title_fullStr Structure, function and druggability of the African trypanosome flagellum
title_full_unstemmed Structure, function and druggability of the African trypanosome flagellum
title_short Structure, function and druggability of the African trypanosome flagellum
title_sort structure, function and druggability of the african trypanosome flagellum
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323424/
https://www.ncbi.nlm.nih.gov/pubmed/35616248
http://dx.doi.org/10.1002/jcp.30778
work_keys_str_mv AT saezcondejulia structurefunctionanddruggabilityoftheafricantrypanosomeflagellum
AT deansamuel structurefunctionanddruggabilityoftheafricantrypanosomeflagellum