Postoperative Ketoacidosis With Hypoglycemia in a Nondiabetic Patient Taking Dapagliflozin for Heart Failure: A Case Report

Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are relatively new antidiabetic drugs, which have been recently approved for heart failure treatment. Although treatment interruption is recommended 3 to 4 days before surgery, it is unclear whether SGLT-2 inhibitors should be discontinued when pres...

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Detalles Bibliográficos
Autores principales: Seki, Hiroyuki, Watanabe, Hidenobu, Yorozu, Tomoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323548/
https://www.ncbi.nlm.nih.gov/pubmed/35285818
http://dx.doi.org/10.1213/XAA.0000000000001570
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author Seki, Hiroyuki
Watanabe, Hidenobu
Yorozu, Tomoko
author_facet Seki, Hiroyuki
Watanabe, Hidenobu
Yorozu, Tomoko
author_sort Seki, Hiroyuki
collection PubMed
description Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are relatively new antidiabetic drugs, which have been recently approved for heart failure treatment. Although treatment interruption is recommended 3 to 4 days before surgery, it is unclear whether SGLT-2 inhibitors should be discontinued when prescribed for heart failure treatment. We describe a case of postoperative ketoacidosis with hypoglycemia in an 83-year-old woman who took dapagliflozin for heart failure and underwent transcatheter aortic valve replacement. She was nondiabetic and took dapagliflozin on the day of the procedure. This case suggests the need to discontinue SGLT-2 inhibitors ahead of the day of surgery when used for heart failure.
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spelling pubmed-93235482022-08-03 Postoperative Ketoacidosis With Hypoglycemia in a Nondiabetic Patient Taking Dapagliflozin for Heart Failure: A Case Report Seki, Hiroyuki Watanabe, Hidenobu Yorozu, Tomoko A A Pract Case Report Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are relatively new antidiabetic drugs, which have been recently approved for heart failure treatment. Although treatment interruption is recommended 3 to 4 days before surgery, it is unclear whether SGLT-2 inhibitors should be discontinued when prescribed for heart failure treatment. We describe a case of postoperative ketoacidosis with hypoglycemia in an 83-year-old woman who took dapagliflozin for heart failure and underwent transcatheter aortic valve replacement. She was nondiabetic and took dapagliflozin on the day of the procedure. This case suggests the need to discontinue SGLT-2 inhibitors ahead of the day of surgery when used for heart failure. Lippincott Williams & Wilkins 2022-03-09 /pmc/articles/PMC9323548/ /pubmed/35285818 http://dx.doi.org/10.1213/XAA.0000000000001570 Text en Copyright © 2022 International Anesthesia Research Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Seki, Hiroyuki
Watanabe, Hidenobu
Yorozu, Tomoko
Postoperative Ketoacidosis With Hypoglycemia in a Nondiabetic Patient Taking Dapagliflozin for Heart Failure: A Case Report
title Postoperative Ketoacidosis With Hypoglycemia in a Nondiabetic Patient Taking Dapagliflozin for Heart Failure: A Case Report
title_full Postoperative Ketoacidosis With Hypoglycemia in a Nondiabetic Patient Taking Dapagliflozin for Heart Failure: A Case Report
title_fullStr Postoperative Ketoacidosis With Hypoglycemia in a Nondiabetic Patient Taking Dapagliflozin for Heart Failure: A Case Report
title_full_unstemmed Postoperative Ketoacidosis With Hypoglycemia in a Nondiabetic Patient Taking Dapagliflozin for Heart Failure: A Case Report
title_short Postoperative Ketoacidosis With Hypoglycemia in a Nondiabetic Patient Taking Dapagliflozin for Heart Failure: A Case Report
title_sort postoperative ketoacidosis with hypoglycemia in a nondiabetic patient taking dapagliflozin for heart failure: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323548/
https://www.ncbi.nlm.nih.gov/pubmed/35285818
http://dx.doi.org/10.1213/XAA.0000000000001570
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AT yorozutomoko postoperativeketoacidosiswithhypoglycemiainanondiabeticpatienttakingdapagliflozinforheartfailureacasereport

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