Mutant p53, the Mevalonate Pathway and the Tumor Microenvironment Regulate Tumor Response to Statin Therapy

SIMPLE SUMMARY: For tumors to initiate and sustain rapid growth, they need to alter their metabolic reprograming to support this growth. While many oncogenes upregulate metabolic pathways in cancer, here, we focus on how mutant p53 interacts with the mevalonate pathway (MVA) and functions as a conti...

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Detalles Bibliográficos
Autores principales: Pereira, Madison, Matuszewska, Kathy, Glogova, Alice, Petrik, Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323637/
https://www.ncbi.nlm.nih.gov/pubmed/35884561
http://dx.doi.org/10.3390/cancers14143500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323637/
https://www.ncbi.nlm.nih.gov/pubmed/35884561
http://dx.doi.org/10.3390/cancers14143500

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