Cargando…
Mutant p53, the Mevalonate Pathway and the Tumor Microenvironment Regulate Tumor Response to Statin Therapy
SIMPLE SUMMARY: For tumors to initiate and sustain rapid growth, they need to alter their metabolic reprograming to support this growth. While many oncogenes upregulate metabolic pathways in cancer, here, we focus on how mutant p53 interacts with the mevalonate pathway (MVA) and functions as a conti...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323637/ https://www.ncbi.nlm.nih.gov/pubmed/35884561 http://dx.doi.org/10.3390/cancers14143500 |