Schistosome Sulfotransferases: Mode of Action, Expression and Localization

Oxamniquine (OXA) is a prodrug activated by a sulfotransferase (SULT) that was only active against Schistosoma mansoni. We have reengineered OXA to be effective against S. haematobium and S. japonicum. Three derivatives stand out, CIDD-0066790, CIDD-0072229, and CIDD-0149830 as they kill all three m...

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Detalles Bibliográficos
Autores principales: Guzman, Meghan A., Rugel, Anastasia, Alwan, Sevan N., Tarpley, Reid, Taylor, Alexander B., Chevalier, Frédéric D., Wendt, George R., Collins, James J., Anderson, Timothy J. C., McHardy, Stanton F., LoVerde, Philip T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323829/
https://www.ncbi.nlm.nih.gov/pubmed/35890311
http://dx.doi.org/10.3390/pharmaceutics14071416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323829/
https://www.ncbi.nlm.nih.gov/pubmed/35890311
http://dx.doi.org/10.3390/pharmaceutics14071416

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