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Piperidine-Iodine as Efficient Dual Catalyst for the One-Pot, Three-Component Synthesis of Coumarin-3-Carboxamides
A simple and efficient one-pot, three-component synthetic method for the preparation of coumarin-3-carboxamides was carried out by the reaction of salicylaldehyde, aliphatic primary/secondary amines, and diethylmalonate. The protocol employs piperidine-iodine as a dual system catalyst and ethanol, a...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323834/ https://www.ncbi.nlm.nih.gov/pubmed/35889530 http://dx.doi.org/10.3390/molecules27144659 |
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| author | Velasco, Manuel Romero-Ceronio, Nancy Torralba, Rosalía Hernández Abreu, Oswaldo Vilchis-Reyes, Miguel A. Alarcón-Matus, Erika Ramos-Rivera, Erika M. Aparicio, David M. Jiménez, Jacqueline Aguilar García, Eric Cruz Cruz, David Villegas Gómez, Clarisa Alvarado, Cuauhtémoc |
| author_facet | Velasco, Manuel Romero-Ceronio, Nancy Torralba, Rosalía Hernández Abreu, Oswaldo Vilchis-Reyes, Miguel A. Alarcón-Matus, Erika Ramos-Rivera, Erika M. Aparicio, David M. Jiménez, Jacqueline Aguilar García, Eric Cruz Cruz, David Villegas Gómez, Clarisa Alvarado, Cuauhtémoc |
| author_sort | Velasco, Manuel |
| collection | PubMed |
| description | A simple and efficient one-pot, three-component synthetic method for the preparation of coumarin-3-carboxamides was carried out by the reaction of salicylaldehyde, aliphatic primary/secondary amines, and diethylmalonate. The protocol employs piperidine-iodine as a dual system catalyst and ethanol, a green solvent. The main advantages of this approach are that it is a metal-free and clean reaction, has low catalyst loading, and requires no tedious workup. |
| format | Online Article Text |
| id | pubmed-9323834 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-93238342022-07-27 Piperidine-Iodine as Efficient Dual Catalyst for the One-Pot, Three-Component Synthesis of Coumarin-3-Carboxamides Velasco, Manuel Romero-Ceronio, Nancy Torralba, Rosalía Hernández Abreu, Oswaldo Vilchis-Reyes, Miguel A. Alarcón-Matus, Erika Ramos-Rivera, Erika M. Aparicio, David M. Jiménez, Jacqueline Aguilar García, Eric Cruz Cruz, David Villegas Gómez, Clarisa Alvarado, Cuauhtémoc Molecules Article A simple and efficient one-pot, three-component synthetic method for the preparation of coumarin-3-carboxamides was carried out by the reaction of salicylaldehyde, aliphatic primary/secondary amines, and diethylmalonate. The protocol employs piperidine-iodine as a dual system catalyst and ethanol, a green solvent. The main advantages of this approach are that it is a metal-free and clean reaction, has low catalyst loading, and requires no tedious workup. MDPI 2022-07-21 /pmc/articles/PMC9323834/ /pubmed/35889530 http://dx.doi.org/10.3390/molecules27144659 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Velasco, Manuel Romero-Ceronio, Nancy Torralba, Rosalía Hernández Abreu, Oswaldo Vilchis-Reyes, Miguel A. Alarcón-Matus, Erika Ramos-Rivera, Erika M. Aparicio, David M. Jiménez, Jacqueline Aguilar García, Eric Cruz Cruz, David Villegas Gómez, Clarisa Alvarado, Cuauhtémoc Piperidine-Iodine as Efficient Dual Catalyst for the One-Pot, Three-Component Synthesis of Coumarin-3-Carboxamides |
| title | Piperidine-Iodine as Efficient Dual Catalyst for the One-Pot, Three-Component Synthesis of Coumarin-3-Carboxamides |
| title_full | Piperidine-Iodine as Efficient Dual Catalyst for the One-Pot, Three-Component Synthesis of Coumarin-3-Carboxamides |
| title_fullStr | Piperidine-Iodine as Efficient Dual Catalyst for the One-Pot, Three-Component Synthesis of Coumarin-3-Carboxamides |
| title_full_unstemmed | Piperidine-Iodine as Efficient Dual Catalyst for the One-Pot, Three-Component Synthesis of Coumarin-3-Carboxamides |
| title_short | Piperidine-Iodine as Efficient Dual Catalyst for the One-Pot, Three-Component Synthesis of Coumarin-3-Carboxamides |
| title_sort | piperidine-iodine as efficient dual catalyst for the one-pot, three-component synthesis of coumarin-3-carboxamides |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323834/ https://www.ncbi.nlm.nih.gov/pubmed/35889530 http://dx.doi.org/10.3390/molecules27144659 |
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