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Fasting Proinsulin Independently Predicts Incident Type 2 Diabetes in the General Population
Fasting proinsulin levels may serve as a marker of β-cell dysfunction and predict type 2 diabetes (T2D) development. Kidneys have been found to be a major site for the degradation of proinsulin. We aimed to evaluate the predictive value of proinsulin for the risk of incident T2D added to a base mode...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323856/ https://www.ncbi.nlm.nih.gov/pubmed/35887628 http://dx.doi.org/10.3390/jpm12071131 |
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author | Sokooti, Sara Dam, Wendy A. Szili-Torok, Tamas Gloerich, Jolein van Gool, Alain J. Post, Adrian de Borst, Martin H. Gansevoort, Ron T. Heerspink, Hiddo J. L. Dullaart, Robin P. F. Bakker, Stephan J. L. |
author_facet | Sokooti, Sara Dam, Wendy A. Szili-Torok, Tamas Gloerich, Jolein van Gool, Alain J. Post, Adrian de Borst, Martin H. Gansevoort, Ron T. Heerspink, Hiddo J. L. Dullaart, Robin P. F. Bakker, Stephan J. L. |
author_sort | Sokooti, Sara |
collection | PubMed |
description | Fasting proinsulin levels may serve as a marker of β-cell dysfunction and predict type 2 diabetes (T2D) development. Kidneys have been found to be a major site for the degradation of proinsulin. We aimed to evaluate the predictive value of proinsulin for the risk of incident T2D added to a base model of clinical predictors and examined potential effect modification by variables related to kidney function. Proinsulin was measured in plasma with U-PLEX platform using ELISA immunoassay. We included 5001 participants without T2D at baseline and during a median follow up of 7.2 years; 271 participants developed T2D. Higher levels of proinsulin were associated with increased risk of T2D independent of glucose, insulin, C-peptide, and other clinical factors (hazard ratio (HR): 1.28; per 1 SD increase 95% confidence interval (CI): 1.08–1.52). Harrell’s C-index for the Framingham offspring risk score was improved with the addition of proinsulin (p = 0.019). Furthermore, we found effect modification by hypertension (p = 0.019), eGFR (p = 0.020) and urinary albumin excretion (p = 0.034), consistent with an association only present in participants with hypertension or kidney dysfunction. Higher fasting proinsulin level is an independent predictor of incident T2D in the general population, particularly in participants with hypertension or kidney dysfunction. |
format | Online Article Text |
id | pubmed-9323856 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93238562022-07-27 Fasting Proinsulin Independently Predicts Incident Type 2 Diabetes in the General Population Sokooti, Sara Dam, Wendy A. Szili-Torok, Tamas Gloerich, Jolein van Gool, Alain J. Post, Adrian de Borst, Martin H. Gansevoort, Ron T. Heerspink, Hiddo J. L. Dullaart, Robin P. F. Bakker, Stephan J. L. J Pers Med Article Fasting proinsulin levels may serve as a marker of β-cell dysfunction and predict type 2 diabetes (T2D) development. Kidneys have been found to be a major site for the degradation of proinsulin. We aimed to evaluate the predictive value of proinsulin for the risk of incident T2D added to a base model of clinical predictors and examined potential effect modification by variables related to kidney function. Proinsulin was measured in plasma with U-PLEX platform using ELISA immunoassay. We included 5001 participants without T2D at baseline and during a median follow up of 7.2 years; 271 participants developed T2D. Higher levels of proinsulin were associated with increased risk of T2D independent of glucose, insulin, C-peptide, and other clinical factors (hazard ratio (HR): 1.28; per 1 SD increase 95% confidence interval (CI): 1.08–1.52). Harrell’s C-index for the Framingham offspring risk score was improved with the addition of proinsulin (p = 0.019). Furthermore, we found effect modification by hypertension (p = 0.019), eGFR (p = 0.020) and urinary albumin excretion (p = 0.034), consistent with an association only present in participants with hypertension or kidney dysfunction. Higher fasting proinsulin level is an independent predictor of incident T2D in the general population, particularly in participants with hypertension or kidney dysfunction. MDPI 2022-07-12 /pmc/articles/PMC9323856/ /pubmed/35887628 http://dx.doi.org/10.3390/jpm12071131 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sokooti, Sara Dam, Wendy A. Szili-Torok, Tamas Gloerich, Jolein van Gool, Alain J. Post, Adrian de Borst, Martin H. Gansevoort, Ron T. Heerspink, Hiddo J. L. Dullaart, Robin P. F. Bakker, Stephan J. L. Fasting Proinsulin Independently Predicts Incident Type 2 Diabetes in the General Population |
title | Fasting Proinsulin Independently Predicts Incident Type 2 Diabetes in the General Population |
title_full | Fasting Proinsulin Independently Predicts Incident Type 2 Diabetes in the General Population |
title_fullStr | Fasting Proinsulin Independently Predicts Incident Type 2 Diabetes in the General Population |
title_full_unstemmed | Fasting Proinsulin Independently Predicts Incident Type 2 Diabetes in the General Population |
title_short | Fasting Proinsulin Independently Predicts Incident Type 2 Diabetes in the General Population |
title_sort | fasting proinsulin independently predicts incident type 2 diabetes in the general population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323856/ https://www.ncbi.nlm.nih.gov/pubmed/35887628 http://dx.doi.org/10.3390/jpm12071131 |
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