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It Takes Two to Tango: Potential Prognostic Impact of Circulating TGF-Beta and PD-L1 in Pancreatic Cancer

Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with rising incidence and poor prognosis. The lack of reliable prognostic biomarkers hampers the individual evaluation of the survival and recurrence potential. Methods: Here, we investigate the value of plasma level...

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Autores principales: Garajová, Ingrid, Cavazzoni, Andrea, Verze, Michela, Minari, Roberta, Pedrazzi, Giuseppe, Balsano, Rita, Gelsomino, Fabio, Valle, Raffaele Dalla, Digiacomo, Graziana, Giovannetti, Elisa, Leonardi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323895/
https://www.ncbi.nlm.nih.gov/pubmed/35888050
http://dx.doi.org/10.3390/life12070960
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author Garajová, Ingrid
Cavazzoni, Andrea
Verze, Michela
Minari, Roberta
Pedrazzi, Giuseppe
Balsano, Rita
Gelsomino, Fabio
Valle, Raffaele Dalla
Digiacomo, Graziana
Giovannetti, Elisa
Leonardi, Francesco
author_facet Garajová, Ingrid
Cavazzoni, Andrea
Verze, Michela
Minari, Roberta
Pedrazzi, Giuseppe
Balsano, Rita
Gelsomino, Fabio
Valle, Raffaele Dalla
Digiacomo, Graziana
Giovannetti, Elisa
Leonardi, Francesco
author_sort Garajová, Ingrid
collection PubMed
description Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with rising incidence and poor prognosis. The lack of reliable prognostic biomarkers hampers the individual evaluation of the survival and recurrence potential. Methods: Here, we investigate the value of plasma levels of two potential key players in molecular mechanisms underlying PDAC aggressiveness and immune evasion, soluble TGF-beta (sTGF-beta) and sPD-L1, in both metastatic and radically-resected PDAC. To this aim we prospectively enrolled 38 PDAC patients and performed appropriate statistical analyses in order to evaluate their correlation, and role in the prediction of disease relapse/progression, and patients’ outcome. Results: Metastatic patients showed lower levels of circulating sTGF-beta and higher levels of sPD-L1 compared to radically-resected patients. Moreover, a decrease in sTGF-beta levels (but not sPD-L1) was significantly associated with disease relapse in radically-resected patients. We also observed lower sTGF-beta at disease progression after first-line chemotherapy in metastatic patients, though this change was not statistically significant. We found a significant correlation between the levels of sTGF-beta and sPD-L1 before first-line chemotherapy. Conclusions: These findings support the possible interaction of TGF-beta and PD-L1 pathways and suggest that sTGF-beta and sPD-L1 might synergize and be new potential blood-based biomarkers.
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spelling pubmed-93238952022-07-27 It Takes Two to Tango: Potential Prognostic Impact of Circulating TGF-Beta and PD-L1 in Pancreatic Cancer Garajová, Ingrid Cavazzoni, Andrea Verze, Michela Minari, Roberta Pedrazzi, Giuseppe Balsano, Rita Gelsomino, Fabio Valle, Raffaele Dalla Digiacomo, Graziana Giovannetti, Elisa Leonardi, Francesco Life (Basel) Article Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly devastating disease with rising incidence and poor prognosis. The lack of reliable prognostic biomarkers hampers the individual evaluation of the survival and recurrence potential. Methods: Here, we investigate the value of plasma levels of two potential key players in molecular mechanisms underlying PDAC aggressiveness and immune evasion, soluble TGF-beta (sTGF-beta) and sPD-L1, in both metastatic and radically-resected PDAC. To this aim we prospectively enrolled 38 PDAC patients and performed appropriate statistical analyses in order to evaluate their correlation, and role in the prediction of disease relapse/progression, and patients’ outcome. Results: Metastatic patients showed lower levels of circulating sTGF-beta and higher levels of sPD-L1 compared to radically-resected patients. Moreover, a decrease in sTGF-beta levels (but not sPD-L1) was significantly associated with disease relapse in radically-resected patients. We also observed lower sTGF-beta at disease progression after first-line chemotherapy in metastatic patients, though this change was not statistically significant. We found a significant correlation between the levels of sTGF-beta and sPD-L1 before first-line chemotherapy. Conclusions: These findings support the possible interaction of TGF-beta and PD-L1 pathways and suggest that sTGF-beta and sPD-L1 might synergize and be new potential blood-based biomarkers. MDPI 2022-06-26 /pmc/articles/PMC9323895/ /pubmed/35888050 http://dx.doi.org/10.3390/life12070960 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Garajová, Ingrid
Cavazzoni, Andrea
Verze, Michela
Minari, Roberta
Pedrazzi, Giuseppe
Balsano, Rita
Gelsomino, Fabio
Valle, Raffaele Dalla
Digiacomo, Graziana
Giovannetti, Elisa
Leonardi, Francesco
It Takes Two to Tango: Potential Prognostic Impact of Circulating TGF-Beta and PD-L1 in Pancreatic Cancer
title It Takes Two to Tango: Potential Prognostic Impact of Circulating TGF-Beta and PD-L1 in Pancreatic Cancer
title_full It Takes Two to Tango: Potential Prognostic Impact of Circulating TGF-Beta and PD-L1 in Pancreatic Cancer
title_fullStr It Takes Two to Tango: Potential Prognostic Impact of Circulating TGF-Beta and PD-L1 in Pancreatic Cancer
title_full_unstemmed It Takes Two to Tango: Potential Prognostic Impact of Circulating TGF-Beta and PD-L1 in Pancreatic Cancer
title_short It Takes Two to Tango: Potential Prognostic Impact of Circulating TGF-Beta and PD-L1 in Pancreatic Cancer
title_sort it takes two to tango: potential prognostic impact of circulating tgf-beta and pd-l1 in pancreatic cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323895/
https://www.ncbi.nlm.nih.gov/pubmed/35888050
http://dx.doi.org/10.3390/life12070960
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