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Determinants of Left Atrial Compliance in the Metabolic Syndrome: Insights from the “Linosa Study”

The association between left atrial (LA) impairment and cardiovascular diseases (CVD) and between dyslipidaemia and CVD are well known. The present study aims to investigate the relationships between metabolic factors and LA dimensions and compliance, as well as test the hypothesis that metabolic fa...

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Autores principales: Barbier, Paolo, Palazzo Adriano, Edvige, Lucini, Daniela, Pagani, Massimo, Cusumano, Gaspare, De Maria, Beatrice, Dalla Vecchia, Laura Adelaide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323981/
https://www.ncbi.nlm.nih.gov/pubmed/35887541
http://dx.doi.org/10.3390/jpm12071044
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author Barbier, Paolo
Palazzo Adriano, Edvige
Lucini, Daniela
Pagani, Massimo
Cusumano, Gaspare
De Maria, Beatrice
Dalla Vecchia, Laura Adelaide
author_facet Barbier, Paolo
Palazzo Adriano, Edvige
Lucini, Daniela
Pagani, Massimo
Cusumano, Gaspare
De Maria, Beatrice
Dalla Vecchia, Laura Adelaide
author_sort Barbier, Paolo
collection PubMed
description The association between left atrial (LA) impairment and cardiovascular diseases (CVD) and between dyslipidaemia and CVD are well known. The present study aims to investigate the relationships between metabolic factors and LA dimensions and compliance, as well as test the hypothesis that metabolic factors influence LA function independent from hemodynamic mechanisms. Arterial blood pressure (BP), waist and hip circumference, metabolic indices, and a complete echocardiographic assessment were obtained from 148 selected inhabitants (M/F 89/59; age 20–86 years) of Linosa Island, who had no history of CVD. At enrollment, 27.7% of the subjects met the criteria for metabolic syndrome (MetS) and 15.5% for arterial hypertension (HTN). LA compliance was reduced in subjects with MetS compared to those without (53 ± 27% vs. 71 ± 29%, p = 0.04) and was even lower (32 ± 17%, p = 0.01) in those with MetS and HTN. At multiple regression analysis, the presence of MetS independently determined LA maximal area (r = 0.56, p < 0.001), whereas systolic BP and the total cholesterol/HDL cholesterol ratio determined LA compliance (r = 0.41, p < 0.001). In an apparently healthy population with a high prevalence of MetS, dyslipidaemia seems to independently influence LA compliance. At a 5-year follow-up, LA compliance was reduced in both all-cause and CVD mortality groups, and markedly impaired in those who died of CVD. These findings may contribute to understanding the prognostic role of LA function in CVD and strengthen the need for early and accurate lipid control strategies.
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spelling pubmed-93239812022-07-27 Determinants of Left Atrial Compliance in the Metabolic Syndrome: Insights from the “Linosa Study” Barbier, Paolo Palazzo Adriano, Edvige Lucini, Daniela Pagani, Massimo Cusumano, Gaspare De Maria, Beatrice Dalla Vecchia, Laura Adelaide J Pers Med Article The association between left atrial (LA) impairment and cardiovascular diseases (CVD) and between dyslipidaemia and CVD are well known. The present study aims to investigate the relationships between metabolic factors and LA dimensions and compliance, as well as test the hypothesis that metabolic factors influence LA function independent from hemodynamic mechanisms. Arterial blood pressure (BP), waist and hip circumference, metabolic indices, and a complete echocardiographic assessment were obtained from 148 selected inhabitants (M/F 89/59; age 20–86 years) of Linosa Island, who had no history of CVD. At enrollment, 27.7% of the subjects met the criteria for metabolic syndrome (MetS) and 15.5% for arterial hypertension (HTN). LA compliance was reduced in subjects with MetS compared to those without (53 ± 27% vs. 71 ± 29%, p = 0.04) and was even lower (32 ± 17%, p = 0.01) in those with MetS and HTN. At multiple regression analysis, the presence of MetS independently determined LA maximal area (r = 0.56, p < 0.001), whereas systolic BP and the total cholesterol/HDL cholesterol ratio determined LA compliance (r = 0.41, p < 0.001). In an apparently healthy population with a high prevalence of MetS, dyslipidaemia seems to independently influence LA compliance. At a 5-year follow-up, LA compliance was reduced in both all-cause and CVD mortality groups, and markedly impaired in those who died of CVD. These findings may contribute to understanding the prognostic role of LA function in CVD and strengthen the need for early and accurate lipid control strategies. MDPI 2022-06-27 /pmc/articles/PMC9323981/ /pubmed/35887541 http://dx.doi.org/10.3390/jpm12071044 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Barbier, Paolo
Palazzo Adriano, Edvige
Lucini, Daniela
Pagani, Massimo
Cusumano, Gaspare
De Maria, Beatrice
Dalla Vecchia, Laura Adelaide
Determinants of Left Atrial Compliance in the Metabolic Syndrome: Insights from the “Linosa Study”
title Determinants of Left Atrial Compliance in the Metabolic Syndrome: Insights from the “Linosa Study”
title_full Determinants of Left Atrial Compliance in the Metabolic Syndrome: Insights from the “Linosa Study”
title_fullStr Determinants of Left Atrial Compliance in the Metabolic Syndrome: Insights from the “Linosa Study”
title_full_unstemmed Determinants of Left Atrial Compliance in the Metabolic Syndrome: Insights from the “Linosa Study”
title_short Determinants of Left Atrial Compliance in the Metabolic Syndrome: Insights from the “Linosa Study”
title_sort determinants of left atrial compliance in the metabolic syndrome: insights from the “linosa study”
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9323981/
https://www.ncbi.nlm.nih.gov/pubmed/35887541
http://dx.doi.org/10.3390/jpm12071044
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