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Novel Survival Features Generated by Clinical Text Information and Radiomics Features May Improve the Prediction of Ischemic Stroke Outcome

Background: Accurate outcome prediction is of great clinical significance in customizing personalized treatment plans, reducing the situation of poor recovery, and objectively and accurately evaluating the treatment effect. This study intended to evaluate the performance of clinical text information...

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Autores principales: Guo, Yingwei, Yang, Yingjian, Cao, Fengqiu, Li, Wei, Wang, Mingming, Luo, Yu, Guo, Jia, Zaman, Asim, Zeng, Xueqiang, Miu, Xiaoqiang, Li, Longyu, Qiu, Weiyan, Kang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324145/
https://www.ncbi.nlm.nih.gov/pubmed/35885568
http://dx.doi.org/10.3390/diagnostics12071664
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author Guo, Yingwei
Yang, Yingjian
Cao, Fengqiu
Li, Wei
Wang, Mingming
Luo, Yu
Guo, Jia
Zaman, Asim
Zeng, Xueqiang
Miu, Xiaoqiang
Li, Longyu
Qiu, Weiyan
Kang, Yan
author_facet Guo, Yingwei
Yang, Yingjian
Cao, Fengqiu
Li, Wei
Wang, Mingming
Luo, Yu
Guo, Jia
Zaman, Asim
Zeng, Xueqiang
Miu, Xiaoqiang
Li, Longyu
Qiu, Weiyan
Kang, Yan
author_sort Guo, Yingwei
collection PubMed
description Background: Accurate outcome prediction is of great clinical significance in customizing personalized treatment plans, reducing the situation of poor recovery, and objectively and accurately evaluating the treatment effect. This study intended to evaluate the performance of clinical text information (CTI), radiomics features, and survival features (SurvF) for predicting functional outcomes of patients with ischemic stroke. Methods: SurvF was constructed based on CTI and mRS radiomics features (mRSRF) to improve the prediction of the functional outcome in 3 months (90-day mRS). Ten machine learning models predicted functional outcomes in three situations (2-category, 4-category, and 7-category) using seven feature groups constructed by CTI, mRSRF, and SurvF. Results: For 2-category, ALL (CTI + mRSRF+ SurvF) performed best, with an mAUC of 0.884, mAcc of 0.864, mPre of 0.877, mF1 of 0.86, and mRecall of 0.864. For 4-category, ALL also achieved the best mAuc of 0.787, while CTI + SurvF achieved the best score with mAcc = 0.611, mPre = 0.622, mF1 = 0.595, and mRe-call = 0.611. For 7-category, CTI + SurvF performed best, with an mAuc of 0.788, mPre of 0.519, mAcc of 0.529, mF1 of 0.495, and mRecall of 0.47. Conclusions: The above results indicate that mRSRF + CTI can accurately predict functional outcomes in ischemic stroke patients with proper machine learning models. Moreover, combining SurvF will improve the prediction effect compared with the original features. However, limited by the small sample size, further validation on larger and more varied datasets is necessary.
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spelling pubmed-93241452022-07-27 Novel Survival Features Generated by Clinical Text Information and Radiomics Features May Improve the Prediction of Ischemic Stroke Outcome Guo, Yingwei Yang, Yingjian Cao, Fengqiu Li, Wei Wang, Mingming Luo, Yu Guo, Jia Zaman, Asim Zeng, Xueqiang Miu, Xiaoqiang Li, Longyu Qiu, Weiyan Kang, Yan Diagnostics (Basel) Article Background: Accurate outcome prediction is of great clinical significance in customizing personalized treatment plans, reducing the situation of poor recovery, and objectively and accurately evaluating the treatment effect. This study intended to evaluate the performance of clinical text information (CTI), radiomics features, and survival features (SurvF) for predicting functional outcomes of patients with ischemic stroke. Methods: SurvF was constructed based on CTI and mRS radiomics features (mRSRF) to improve the prediction of the functional outcome in 3 months (90-day mRS). Ten machine learning models predicted functional outcomes in three situations (2-category, 4-category, and 7-category) using seven feature groups constructed by CTI, mRSRF, and SurvF. Results: For 2-category, ALL (CTI + mRSRF+ SurvF) performed best, with an mAUC of 0.884, mAcc of 0.864, mPre of 0.877, mF1 of 0.86, and mRecall of 0.864. For 4-category, ALL also achieved the best mAuc of 0.787, while CTI + SurvF achieved the best score with mAcc = 0.611, mPre = 0.622, mF1 = 0.595, and mRe-call = 0.611. For 7-category, CTI + SurvF performed best, with an mAuc of 0.788, mPre of 0.519, mAcc of 0.529, mF1 of 0.495, and mRecall of 0.47. Conclusions: The above results indicate that mRSRF + CTI can accurately predict functional outcomes in ischemic stroke patients with proper machine learning models. Moreover, combining SurvF will improve the prediction effect compared with the original features. However, limited by the small sample size, further validation on larger and more varied datasets is necessary. MDPI 2022-07-08 /pmc/articles/PMC9324145/ /pubmed/35885568 http://dx.doi.org/10.3390/diagnostics12071664 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guo, Yingwei
Yang, Yingjian
Cao, Fengqiu
Li, Wei
Wang, Mingming
Luo, Yu
Guo, Jia
Zaman, Asim
Zeng, Xueqiang
Miu, Xiaoqiang
Li, Longyu
Qiu, Weiyan
Kang, Yan
Novel Survival Features Generated by Clinical Text Information and Radiomics Features May Improve the Prediction of Ischemic Stroke Outcome
title Novel Survival Features Generated by Clinical Text Information and Radiomics Features May Improve the Prediction of Ischemic Stroke Outcome
title_full Novel Survival Features Generated by Clinical Text Information and Radiomics Features May Improve the Prediction of Ischemic Stroke Outcome
title_fullStr Novel Survival Features Generated by Clinical Text Information and Radiomics Features May Improve the Prediction of Ischemic Stroke Outcome
title_full_unstemmed Novel Survival Features Generated by Clinical Text Information and Radiomics Features May Improve the Prediction of Ischemic Stroke Outcome
title_short Novel Survival Features Generated by Clinical Text Information and Radiomics Features May Improve the Prediction of Ischemic Stroke Outcome
title_sort novel survival features generated by clinical text information and radiomics features may improve the prediction of ischemic stroke outcome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324145/
https://www.ncbi.nlm.nih.gov/pubmed/35885568
http://dx.doi.org/10.3390/diagnostics12071664
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