Synthesis of Novel Glycolipid Mimetics of Heparan Sulfate and Their Application in Colorectal Cancer Treatment in a Mouse Model

Heparan sulfate (HS) is a highly sulfated natural carbohydrate that plays crucial roles in cancer, inflammation, and angiogenesis. Heparanase (HPSE) is the sole HS degrading endoglycosidase that cleaves HS at structure‐dependent sites along the polysaccharide chain. Overexpression of HPSE by cancer...

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Detalles Bibliográficos
Autores principales: Spijkers‐Shaw, Sam, Campbell, Katrin, Shields, Nicholas J., Miller, John H., Rendle, Phillip M., Jiao, Wanting, Young, Sarah L., Zubkova, Olga V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324168/
https://www.ncbi.nlm.nih.gov/pubmed/35427432
http://dx.doi.org/10.1002/asia.202200228

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