Five New Polyoxypregnane Glycosides from the Vines of Aspidopterys obcordata and Their Antinephrolithiasis Activity

From the dried vines of Aspidopterys obcordata Hemsl, five new polyoxypregnane glycosides, named obcordatas J–N (1–5), were obtained. Their structures were fully elucidated and characterized by HRESIMS and extensive spectroscopic data. In addition, all of the new compounds were screened for their an...

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Autores principales: Sun, Zhaocui, Chen, Meiying, Li, Qinglong, Ma, Guoxu, Wu, Haifeng, Yang, Junshan, Li, Yihang, Xu, Xudong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324186/
https://www.ncbi.nlm.nih.gov/pubmed/35889467
http://dx.doi.org/10.3390/molecules27144596
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author Sun, Zhaocui
Chen, Meiying
Li, Qinglong
Ma, Guoxu
Wu, Haifeng
Yang, Junshan
Li, Yihang
Xu, Xudong
author_facet Sun, Zhaocui
Chen, Meiying
Li, Qinglong
Ma, Guoxu
Wu, Haifeng
Yang, Junshan
Li, Yihang
Xu, Xudong
author_sort Sun, Zhaocui
collection PubMed
description From the dried vines of Aspidopterys obcordata Hemsl, five new polyoxypregnane glycosides, named obcordatas J–N (1–5), were obtained. Their structures were fully elucidated and characterized by HRESIMS and extensive spectroscopic data. In addition, all of the new compounds were screened for their antinephrolithiasis activity in vitro. The results showed that compounds 1–3 have prominent protective effects on calcium oxalate crystal-induced human kidney 2 (HK-2) cells, with EC(50) values ranging from 6.72 to 14.00 μM, which is consistent with the application value of A. obcordata in folk medicine for kidney stones.
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spelling pubmed-93241862022-07-27 Five New Polyoxypregnane Glycosides from the Vines of Aspidopterys obcordata and Their Antinephrolithiasis Activity Sun, Zhaocui Chen, Meiying Li, Qinglong Ma, Guoxu Wu, Haifeng Yang, Junshan Li, Yihang Xu, Xudong Molecules Article From the dried vines of Aspidopterys obcordata Hemsl, five new polyoxypregnane glycosides, named obcordatas J–N (1–5), were obtained. Their structures were fully elucidated and characterized by HRESIMS and extensive spectroscopic data. In addition, all of the new compounds were screened for their antinephrolithiasis activity in vitro. The results showed that compounds 1–3 have prominent protective effects on calcium oxalate crystal-induced human kidney 2 (HK-2) cells, with EC(50) values ranging from 6.72 to 14.00 μM, which is consistent with the application value of A. obcordata in folk medicine for kidney stones. MDPI 2022-07-19 /pmc/articles/PMC9324186/ /pubmed/35889467 http://dx.doi.org/10.3390/molecules27144596 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Zhaocui
Chen, Meiying
Li, Qinglong
Ma, Guoxu
Wu, Haifeng
Yang, Junshan
Li, Yihang
Xu, Xudong
Five New Polyoxypregnane Glycosides from the Vines of Aspidopterys obcordata and Their Antinephrolithiasis Activity
title Five New Polyoxypregnane Glycosides from the Vines of Aspidopterys obcordata and Their Antinephrolithiasis Activity
title_full Five New Polyoxypregnane Glycosides from the Vines of Aspidopterys obcordata and Their Antinephrolithiasis Activity
title_fullStr Five New Polyoxypregnane Glycosides from the Vines of Aspidopterys obcordata and Their Antinephrolithiasis Activity
title_full_unstemmed Five New Polyoxypregnane Glycosides from the Vines of Aspidopterys obcordata and Their Antinephrolithiasis Activity
title_short Five New Polyoxypregnane Glycosides from the Vines of Aspidopterys obcordata and Their Antinephrolithiasis Activity
title_sort five new polyoxypregnane glycosides from the vines of aspidopterys obcordata and their antinephrolithiasis activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324186/
https://www.ncbi.nlm.nih.gov/pubmed/35889467
http://dx.doi.org/10.3390/molecules27144596
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