Venous blood for the analysis of acid–base status in a model of septic shock

OBJECTIVE: To determine the relationship between arterial and venous acid–base status in a model of septic shock. METHODS: Paired samples (n = 435) of arterial and femoral venous blood from 57 sheep (47 septic, 10 non‐septic) managed with protocol‐guided ventilation, sedation, parenteral fluids and...

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Detalles Bibliográficos
Autores principales: Maiden, Matthew J, Fraser, Jonathan D, Finnis, Mark E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Publishing Asia Pty Ltd 2022
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324208/
https://www.ncbi.nlm.nih.gov/pubmed/35398968
http://dx.doi.org/10.1111/1742-6723.13975
Descripción
Sumario:OBJECTIVE: To determine the relationship between arterial and venous acid–base status in a model of septic shock. METHODS: Paired samples (n = 435) of arterial and femoral venous blood from 57 sheep (47 septic, 10 non‐septic) managed with protocol‐guided ventilation, sedation, parenteral fluids and inotropic support. RESULTS: The arterial‐venous difference in acid–base parameters was similar with and without sepsis. There was a consistent arterio‐venous relationship for metabolic (pH, lactate, bicarbonate, base excess), but not respiratory parameters (partial pressures of oxygen, carbon dioxide, and haemoglobin‐oxygen saturation), independent of sepsis. CONCLUSIONS: Venous blood provides a reliable measure of metabolic but not respiratory disturbance.

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