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Vitamin A in Skin and Hair: An Update

Vitamin A is a fat-soluble micronutrient necessary for the growth of healthy skin and hair. However, both too little and too much vitamin A has deleterious effects. Retinoic acid and retinal are the main active metabolites of vitamin A. Retinoic acid dose-dependently regulates hair follicle stem cel...

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Autores principales: VanBuren, Christine A., Everts, Helen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324272/
https://www.ncbi.nlm.nih.gov/pubmed/35889909
http://dx.doi.org/10.3390/nu14142952
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author VanBuren, Christine A.
Everts, Helen B.
author_facet VanBuren, Christine A.
Everts, Helen B.
author_sort VanBuren, Christine A.
collection PubMed
description Vitamin A is a fat-soluble micronutrient necessary for the growth of healthy skin and hair. However, both too little and too much vitamin A has deleterious effects. Retinoic acid and retinal are the main active metabolites of vitamin A. Retinoic acid dose-dependently regulates hair follicle stem cells, influencing the functioning of the hair cycle, wound healing, and melanocyte stem cells. Retinoic acid also influences melanocyte differentiation and proliferation in a dose-dependent and temporal manner. Levels of retinoids decline when exposed to ultraviolet irradiation in the skin. Retinal is necessary for the phototransduction cascade that initiates melanogenesis but the source of that retinal is currently unknown. This review discusses new research on retinoids and their effects on the skin and hair.
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spelling pubmed-93242722022-07-27 Vitamin A in Skin and Hair: An Update VanBuren, Christine A. Everts, Helen B. Nutrients Review Vitamin A is a fat-soluble micronutrient necessary for the growth of healthy skin and hair. However, both too little and too much vitamin A has deleterious effects. Retinoic acid and retinal are the main active metabolites of vitamin A. Retinoic acid dose-dependently regulates hair follicle stem cells, influencing the functioning of the hair cycle, wound healing, and melanocyte stem cells. Retinoic acid also influences melanocyte differentiation and proliferation in a dose-dependent and temporal manner. Levels of retinoids decline when exposed to ultraviolet irradiation in the skin. Retinal is necessary for the phototransduction cascade that initiates melanogenesis but the source of that retinal is currently unknown. This review discusses new research on retinoids and their effects on the skin and hair. MDPI 2022-07-19 /pmc/articles/PMC9324272/ /pubmed/35889909 http://dx.doi.org/10.3390/nu14142952 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
VanBuren, Christine A.
Everts, Helen B.
Vitamin A in Skin and Hair: An Update
title Vitamin A in Skin and Hair: An Update
title_full Vitamin A in Skin and Hair: An Update
title_fullStr Vitamin A in Skin and Hair: An Update
title_full_unstemmed Vitamin A in Skin and Hair: An Update
title_short Vitamin A in Skin and Hair: An Update
title_sort vitamin a in skin and hair: an update
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324272/
https://www.ncbi.nlm.nih.gov/pubmed/35889909
http://dx.doi.org/10.3390/nu14142952
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