Cargando…
The Chaperone System in Breast Cancer: Roles and Therapeutic Prospects of the Molecular Chaperones Hsp27, Hsp60, Hsp70, and Hsp90
Breast cancer (BC) is a major public health problem, with key pieces of information needed for developing preventive and curative measures still missing. For example, the participation of the chaperone system (CS) in carcinogenesis and anti-cancer responses is poorly understood, although it can be p...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324353/ https://www.ncbi.nlm.nih.gov/pubmed/35887137 http://dx.doi.org/10.3390/ijms23147792 |
_version_ | 1784756783074508800 |
---|---|
author | Alberti, Giusi Vergilio, Giuseppe Paladino, Letizia Barone, Rosario Cappello, Francesco Conway de Macario, Everly Macario, Alberto J. L. Bucchieri, Fabio Rappa, Francesca |
author_facet | Alberti, Giusi Vergilio, Giuseppe Paladino, Letizia Barone, Rosario Cappello, Francesco Conway de Macario, Everly Macario, Alberto J. L. Bucchieri, Fabio Rappa, Francesca |
author_sort | Alberti, Giusi |
collection | PubMed |
description | Breast cancer (BC) is a major public health problem, with key pieces of information needed for developing preventive and curative measures still missing. For example, the participation of the chaperone system (CS) in carcinogenesis and anti-cancer responses is poorly understood, although it can be predicted to be a crucial factor in these mechanisms. The chief components of the CS are the molecular chaperones, and here we discuss four of them, Hsp27, Hsp60, Hsp70, and Hsp90, focusing on their pro-carcinogenic roles in BC and potential for developing anti-BC therapies. These chaperones can be targets of negative chaperonotherapy, namely the elimination/blocking/inhibition of the chaperone(s) functioning in favor of BC, using, for instance, Hsp inhibitors. The chaperones can also be employed in immunotherapy against BC as adjuvants, together with BC antigens. Extracellular vesicles (EVs) in BC diagnosis and management are also briefly discussed, considering their potential as easily accessible carriers of biomarkers and as shippers of anti-cancer agents amenable to manipulation and controlled delivery. The data surveyed from many laboratories reveal that, to enhance the understanding of the role of the CS in BS pathogenesis, one must consider the CS as a physiological system, encompassing diverse members throughout the body and interacting with the ubiquitin–proteasome system, the chaperone-mediated autophagy machinery, and the immune system (IS). An integrated view of the CS, including its functional partners and considering its highly dynamic nature with EVs transporting CS components to reach all the cell compartments in which they are needed, opens as yet unexplored pathways leading to carcinogenesis that are amenable to interference by anti-cancer treatments centered on CS components, such as the molecular chaperones. |
format | Online Article Text |
id | pubmed-9324353 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93243532022-07-27 The Chaperone System in Breast Cancer: Roles and Therapeutic Prospects of the Molecular Chaperones Hsp27, Hsp60, Hsp70, and Hsp90 Alberti, Giusi Vergilio, Giuseppe Paladino, Letizia Barone, Rosario Cappello, Francesco Conway de Macario, Everly Macario, Alberto J. L. Bucchieri, Fabio Rappa, Francesca Int J Mol Sci Review Breast cancer (BC) is a major public health problem, with key pieces of information needed for developing preventive and curative measures still missing. For example, the participation of the chaperone system (CS) in carcinogenesis and anti-cancer responses is poorly understood, although it can be predicted to be a crucial factor in these mechanisms. The chief components of the CS are the molecular chaperones, and here we discuss four of them, Hsp27, Hsp60, Hsp70, and Hsp90, focusing on their pro-carcinogenic roles in BC and potential for developing anti-BC therapies. These chaperones can be targets of negative chaperonotherapy, namely the elimination/blocking/inhibition of the chaperone(s) functioning in favor of BC, using, for instance, Hsp inhibitors. The chaperones can also be employed in immunotherapy against BC as adjuvants, together with BC antigens. Extracellular vesicles (EVs) in BC diagnosis and management are also briefly discussed, considering their potential as easily accessible carriers of biomarkers and as shippers of anti-cancer agents amenable to manipulation and controlled delivery. The data surveyed from many laboratories reveal that, to enhance the understanding of the role of the CS in BS pathogenesis, one must consider the CS as a physiological system, encompassing diverse members throughout the body and interacting with the ubiquitin–proteasome system, the chaperone-mediated autophagy machinery, and the immune system (IS). An integrated view of the CS, including its functional partners and considering its highly dynamic nature with EVs transporting CS components to reach all the cell compartments in which they are needed, opens as yet unexplored pathways leading to carcinogenesis that are amenable to interference by anti-cancer treatments centered on CS components, such as the molecular chaperones. MDPI 2022-07-14 /pmc/articles/PMC9324353/ /pubmed/35887137 http://dx.doi.org/10.3390/ijms23147792 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Alberti, Giusi Vergilio, Giuseppe Paladino, Letizia Barone, Rosario Cappello, Francesco Conway de Macario, Everly Macario, Alberto J. L. Bucchieri, Fabio Rappa, Francesca The Chaperone System in Breast Cancer: Roles and Therapeutic Prospects of the Molecular Chaperones Hsp27, Hsp60, Hsp70, and Hsp90 |
title | The Chaperone System in Breast Cancer: Roles and Therapeutic Prospects of the Molecular Chaperones Hsp27, Hsp60, Hsp70, and Hsp90 |
title_full | The Chaperone System in Breast Cancer: Roles and Therapeutic Prospects of the Molecular Chaperones Hsp27, Hsp60, Hsp70, and Hsp90 |
title_fullStr | The Chaperone System in Breast Cancer: Roles and Therapeutic Prospects of the Molecular Chaperones Hsp27, Hsp60, Hsp70, and Hsp90 |
title_full_unstemmed | The Chaperone System in Breast Cancer: Roles and Therapeutic Prospects of the Molecular Chaperones Hsp27, Hsp60, Hsp70, and Hsp90 |
title_short | The Chaperone System in Breast Cancer: Roles and Therapeutic Prospects of the Molecular Chaperones Hsp27, Hsp60, Hsp70, and Hsp90 |
title_sort | chaperone system in breast cancer: roles and therapeutic prospects of the molecular chaperones hsp27, hsp60, hsp70, and hsp90 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324353/ https://www.ncbi.nlm.nih.gov/pubmed/35887137 http://dx.doi.org/10.3390/ijms23147792 |
work_keys_str_mv | AT albertigiusi thechaperonesysteminbreastcancerrolesandtherapeuticprospectsofthemolecularchaperoneshsp27hsp60hsp70andhsp90 AT vergiliogiuseppe thechaperonesysteminbreastcancerrolesandtherapeuticprospectsofthemolecularchaperoneshsp27hsp60hsp70andhsp90 AT paladinoletizia thechaperonesysteminbreastcancerrolesandtherapeuticprospectsofthemolecularchaperoneshsp27hsp60hsp70andhsp90 AT baronerosario thechaperonesysteminbreastcancerrolesandtherapeuticprospectsofthemolecularchaperoneshsp27hsp60hsp70andhsp90 AT cappellofrancesco thechaperonesysteminbreastcancerrolesandtherapeuticprospectsofthemolecularchaperoneshsp27hsp60hsp70andhsp90 AT conwaydemacarioeverly thechaperonesysteminbreastcancerrolesandtherapeuticprospectsofthemolecularchaperoneshsp27hsp60hsp70andhsp90 AT macarioalbertojl thechaperonesysteminbreastcancerrolesandtherapeuticprospectsofthemolecularchaperoneshsp27hsp60hsp70andhsp90 AT bucchierifabio thechaperonesysteminbreastcancerrolesandtherapeuticprospectsofthemolecularchaperoneshsp27hsp60hsp70andhsp90 AT rappafrancesca thechaperonesysteminbreastcancerrolesandtherapeuticprospectsofthemolecularchaperoneshsp27hsp60hsp70andhsp90 AT albertigiusi chaperonesysteminbreastcancerrolesandtherapeuticprospectsofthemolecularchaperoneshsp27hsp60hsp70andhsp90 AT vergiliogiuseppe chaperonesysteminbreastcancerrolesandtherapeuticprospectsofthemolecularchaperoneshsp27hsp60hsp70andhsp90 AT paladinoletizia chaperonesysteminbreastcancerrolesandtherapeuticprospectsofthemolecularchaperoneshsp27hsp60hsp70andhsp90 AT baronerosario chaperonesysteminbreastcancerrolesandtherapeuticprospectsofthemolecularchaperoneshsp27hsp60hsp70andhsp90 AT cappellofrancesco chaperonesysteminbreastcancerrolesandtherapeuticprospectsofthemolecularchaperoneshsp27hsp60hsp70andhsp90 AT conwaydemacarioeverly chaperonesysteminbreastcancerrolesandtherapeuticprospectsofthemolecularchaperoneshsp27hsp60hsp70andhsp90 AT macarioalbertojl chaperonesysteminbreastcancerrolesandtherapeuticprospectsofthemolecularchaperoneshsp27hsp60hsp70andhsp90 AT bucchierifabio chaperonesysteminbreastcancerrolesandtherapeuticprospectsofthemolecularchaperoneshsp27hsp60hsp70andhsp90 AT rappafrancesca chaperonesysteminbreastcancerrolesandtherapeuticprospectsofthemolecularchaperoneshsp27hsp60hsp70andhsp90 |