Complexed Polymer Film-Forming Spray: An Optimal Delivery System for Secretome of Mesenchymal Stem Cell as Diabetic Wound Dressing?

Diabetes-related wounds have physiological factors that make healing more complicated. High sugar levels can increase microbial infection risk while limiting nutrition and oxygen transfer to the wound area. The secretome of mesenchymal stem cells has been widely known for its efficacy in regenerativ...

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Detalles Bibliográficos
Autores principales: Umar, Abd. Kakhar, Luckanagul, Jittima Amie, Zothantluanga, James H., Sriwidodo, Sriwidodo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324405/
https://www.ncbi.nlm.nih.gov/pubmed/35890165
http://dx.doi.org/10.3390/ph15070867
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author Umar, Abd. Kakhar
Luckanagul, Jittima Amie
Zothantluanga, James H.
Sriwidodo, Sriwidodo
author_facet Umar, Abd. Kakhar
Luckanagul, Jittima Amie
Zothantluanga, James H.
Sriwidodo, Sriwidodo
author_sort Umar, Abd. Kakhar
collection PubMed
description Diabetes-related wounds have physiological factors that make healing more complicated. High sugar levels can increase microbial infection risk while limiting nutrition and oxygen transfer to the wound area. The secretome of mesenchymal stem cells has been widely known for its efficacy in regenerative therapy. However, applying the secretome directly to the wound can reduce its effectiveness. In this review, we examined the literature on synthesizing the combinations of carboxymethyl chitosan, hyaluronic acid, and collagen tripeptides, as well as the possibility of physicochemical properties enhancement of the hydrogel matrix, which could potentially be used as an optimal delivery system of stem cell’s secretome for diabetic wound healing.
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spelling pubmed-93244052022-07-27 Complexed Polymer Film-Forming Spray: An Optimal Delivery System for Secretome of Mesenchymal Stem Cell as Diabetic Wound Dressing? Umar, Abd. Kakhar Luckanagul, Jittima Amie Zothantluanga, James H. Sriwidodo, Sriwidodo Pharmaceuticals (Basel) Opinion Diabetes-related wounds have physiological factors that make healing more complicated. High sugar levels can increase microbial infection risk while limiting nutrition and oxygen transfer to the wound area. The secretome of mesenchymal stem cells has been widely known for its efficacy in regenerative therapy. However, applying the secretome directly to the wound can reduce its effectiveness. In this review, we examined the literature on synthesizing the combinations of carboxymethyl chitosan, hyaluronic acid, and collagen tripeptides, as well as the possibility of physicochemical properties enhancement of the hydrogel matrix, which could potentially be used as an optimal delivery system of stem cell’s secretome for diabetic wound healing. MDPI 2022-07-14 /pmc/articles/PMC9324405/ /pubmed/35890165 http://dx.doi.org/10.3390/ph15070867 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Opinion
Umar, Abd. Kakhar
Luckanagul, Jittima Amie
Zothantluanga, James H.
Sriwidodo, Sriwidodo
Complexed Polymer Film-Forming Spray: An Optimal Delivery System for Secretome of Mesenchymal Stem Cell as Diabetic Wound Dressing?
title Complexed Polymer Film-Forming Spray: An Optimal Delivery System for Secretome of Mesenchymal Stem Cell as Diabetic Wound Dressing?
title_full Complexed Polymer Film-Forming Spray: An Optimal Delivery System for Secretome of Mesenchymal Stem Cell as Diabetic Wound Dressing?
title_fullStr Complexed Polymer Film-Forming Spray: An Optimal Delivery System for Secretome of Mesenchymal Stem Cell as Diabetic Wound Dressing?
title_full_unstemmed Complexed Polymer Film-Forming Spray: An Optimal Delivery System for Secretome of Mesenchymal Stem Cell as Diabetic Wound Dressing?
title_short Complexed Polymer Film-Forming Spray: An Optimal Delivery System for Secretome of Mesenchymal Stem Cell as Diabetic Wound Dressing?
title_sort complexed polymer film-forming spray: an optimal delivery system for secretome of mesenchymal stem cell as diabetic wound dressing?
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324405/
https://www.ncbi.nlm.nih.gov/pubmed/35890165
http://dx.doi.org/10.3390/ph15070867
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