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Survey on Untethering of the Spinal Cord and Urological Manifestations among Spina Bifida Patients in Malaysia

The incidence and severity of urinary tract infections (UTIs) due to spina bifida is poorly understood in Malaysia. Tethering of the spinal cord is a pathological fixation of the cord in the vertebral column that can result in neurogenic bladder dysfunction and other neurological problems. It occurs...

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Autores principales: Nisheljeet, Singh, Azizi, Abu Bakar, Palaniandy, Kamalanathan, Ganesan, Dharmendra, Ong, Teng Aik, Alias, Azmi, Rajamanickam, Ramalinggam, Atroosh, Wahib M., Mohd-Zin, Siti Waheeda, Lee-Shamsuddin, Andrea, Nivrenjeet, Singh, Lo, Warren, Abdul-Aziz, Noraishah Mydin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324435/
https://www.ncbi.nlm.nih.gov/pubmed/35884073
http://dx.doi.org/10.3390/children9071090
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author Nisheljeet, Singh
Azizi, Abu Bakar
Palaniandy, Kamalanathan
Ganesan, Dharmendra
Ong, Teng Aik
Alias, Azmi
Rajamanickam, Ramalinggam
Atroosh, Wahib M.
Mohd-Zin, Siti Waheeda
Lee-Shamsuddin, Andrea
Nivrenjeet, Singh
Lo, Warren
Abdul-Aziz, Noraishah Mydin
author_facet Nisheljeet, Singh
Azizi, Abu Bakar
Palaniandy, Kamalanathan
Ganesan, Dharmendra
Ong, Teng Aik
Alias, Azmi
Rajamanickam, Ramalinggam
Atroosh, Wahib M.
Mohd-Zin, Siti Waheeda
Lee-Shamsuddin, Andrea
Nivrenjeet, Singh
Lo, Warren
Abdul-Aziz, Noraishah Mydin
author_sort Nisheljeet, Singh
collection PubMed
description The incidence and severity of urinary tract infections (UTIs) due to spina bifida is poorly understood in Malaysia. Tethering of the spinal cord is a pathological fixation of the cord in the vertebral column that can result in neurogenic bladder dysfunction and other neurological problems. It occurs in patients with spina bifida, and the authors of this study sought to investigate the impact of untethering on the urological manifestations of children with a tethered cord, thereby consolidating a previously known understanding that untethering improves bladder and bowel function. Demographic and clinical data were collected via an online questionnaire and convenient sampling techniques were used. A total of 49 individuals affected by spina bifida participated in this study. UTIs were reported based on patients’ observation of cloudy and smelly urine (67%) as well as urine validation (60%). UTI is defined as the combination of symptoms and factoring in urine culture results that eventually affects the UTI diagnosis in spina bifida individuals irrespective of CISC status. Furthermore, 18% of the respondents reported being prescribed antibiotics even though they had no history of UTI. Therefore, indiscriminate prescription of antibiotics by healthcare workers further compounds the severity of future UTIs. Employing CISC (73%) including stringent usage of sterile catheters (71%) did not prevent patients from getting UTI. Overall, 33% of our respondents reported manageable control of UTI (0–35 years of age). All individuals below the age of 5 (100%, n = 14) were seen to have improved urologically after the untethering surgery under the guidance of the Malaysia NTD support group. Improvement was scored and observed using KUB (Kidneys, Ureters and Bladder) ultrasound surveillance before untethering and continued thereafter. Spina bifida individuals may procure healthy bladder and bowel continence for the rest of their lives provided that neurosurgical and urological treatments were sought soon after birth and continues into adulthood.
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spelling pubmed-93244352022-07-27 Survey on Untethering of the Spinal Cord and Urological Manifestations among Spina Bifida Patients in Malaysia Nisheljeet, Singh Azizi, Abu Bakar Palaniandy, Kamalanathan Ganesan, Dharmendra Ong, Teng Aik Alias, Azmi Rajamanickam, Ramalinggam Atroosh, Wahib M. Mohd-Zin, Siti Waheeda Lee-Shamsuddin, Andrea Nivrenjeet, Singh Lo, Warren Abdul-Aziz, Noraishah Mydin Children (Basel) Article The incidence and severity of urinary tract infections (UTIs) due to spina bifida is poorly understood in Malaysia. Tethering of the spinal cord is a pathological fixation of the cord in the vertebral column that can result in neurogenic bladder dysfunction and other neurological problems. It occurs in patients with spina bifida, and the authors of this study sought to investigate the impact of untethering on the urological manifestations of children with a tethered cord, thereby consolidating a previously known understanding that untethering improves bladder and bowel function. Demographic and clinical data were collected via an online questionnaire and convenient sampling techniques were used. A total of 49 individuals affected by spina bifida participated in this study. UTIs were reported based on patients’ observation of cloudy and smelly urine (67%) as well as urine validation (60%). UTI is defined as the combination of symptoms and factoring in urine culture results that eventually affects the UTI diagnosis in spina bifida individuals irrespective of CISC status. Furthermore, 18% of the respondents reported being prescribed antibiotics even though they had no history of UTI. Therefore, indiscriminate prescription of antibiotics by healthcare workers further compounds the severity of future UTIs. Employing CISC (73%) including stringent usage of sterile catheters (71%) did not prevent patients from getting UTI. Overall, 33% of our respondents reported manageable control of UTI (0–35 years of age). All individuals below the age of 5 (100%, n = 14) were seen to have improved urologically after the untethering surgery under the guidance of the Malaysia NTD support group. Improvement was scored and observed using KUB (Kidneys, Ureters and Bladder) ultrasound surveillance before untethering and continued thereafter. Spina bifida individuals may procure healthy bladder and bowel continence for the rest of their lives provided that neurosurgical and urological treatments were sought soon after birth and continues into adulthood. MDPI 2022-07-21 /pmc/articles/PMC9324435/ /pubmed/35884073 http://dx.doi.org/10.3390/children9071090 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nisheljeet, Singh
Azizi, Abu Bakar
Palaniandy, Kamalanathan
Ganesan, Dharmendra
Ong, Teng Aik
Alias, Azmi
Rajamanickam, Ramalinggam
Atroosh, Wahib M.
Mohd-Zin, Siti Waheeda
Lee-Shamsuddin, Andrea
Nivrenjeet, Singh
Lo, Warren
Abdul-Aziz, Noraishah Mydin
Survey on Untethering of the Spinal Cord and Urological Manifestations among Spina Bifida Patients in Malaysia
title Survey on Untethering of the Spinal Cord and Urological Manifestations among Spina Bifida Patients in Malaysia
title_full Survey on Untethering of the Spinal Cord and Urological Manifestations among Spina Bifida Patients in Malaysia
title_fullStr Survey on Untethering of the Spinal Cord and Urological Manifestations among Spina Bifida Patients in Malaysia
title_full_unstemmed Survey on Untethering of the Spinal Cord and Urological Manifestations among Spina Bifida Patients in Malaysia
title_short Survey on Untethering of the Spinal Cord and Urological Manifestations among Spina Bifida Patients in Malaysia
title_sort survey on untethering of the spinal cord and urological manifestations among spina bifida patients in malaysia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324435/
https://www.ncbi.nlm.nih.gov/pubmed/35884073
http://dx.doi.org/10.3390/children9071090
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