NSD1 Mutations in Sotos Syndrome Induce Differential Expression of Long Noncoding RNAs, miR646 and Genes Controlling the G2/M Checkpoint

An increasing amount of evidence indicates the critical role of the NSD1 gene in Sotos syndrome (SoS), a rare genetic disease, and in tumors. Molecular mechanisms affected by NSD1 mutations are largely uncharacterized. In order to assess the impact of NSD1 haploinsufficiency in the pathogenesis of S...

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Detalles Bibliográficos
Autores principales: Conteduca, Giuseppina, Cangelosi, Davide, Coco, Simona, Malacarne, Michela, Baldo, Chiara, Arado, Alessia, Pinto, Rute, Testa, Barbara, Coviello, Domenico A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324496/
https://www.ncbi.nlm.nih.gov/pubmed/35888078
http://dx.doi.org/10.3390/life12070988

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