Periocular Infection of Mycobacterium avium Complex in a Patient with Interferon-γ Autoantibodies: A Case Report

The neutralizing anti-interferon-γ autoantibody (nAIGA)-associated immunodeficiency is an emerging entity frequently associated with the nontuberculosis mycobacterium (NTM) infection and other opportunistic infections. We present a female patient with a mysterious periocular Mycobacterium avium comp...

Descripción completa

Detalles Bibliográficos
Autores principales: Lo, Tzu-Hui, Tsai, Tou-Yuan, Wang, Lih-Shinn, Huang, Tzu-Lun, Chen, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324542/
https://www.ncbi.nlm.nih.gov/pubmed/35888565
http://dx.doi.org/10.3390/medicina58070846
_version_ 1784756833023426560
author Lo, Tzu-Hui
Tsai, Tou-Yuan
Wang, Lih-Shinn
Huang, Tzu-Lun
Chen, Nancy
author_facet Lo, Tzu-Hui
Tsai, Tou-Yuan
Wang, Lih-Shinn
Huang, Tzu-Lun
Chen, Nancy
author_sort Lo, Tzu-Hui
collection PubMed
description The neutralizing anti-interferon-γ autoantibody (nAIGA)-associated immunodeficiency is an emerging entity frequently associated with the nontuberculosis mycobacterium (NTM) infection and other opportunistic infections. We present a female patient with a mysterious periocular Mycobacterium avium complex (MAC) infection, accompanied by sequential opportunistic infections including Salmollelosis and herpes zoster infection. Her condition stabilized after long-term antimycobacterial treatment. Nevertheless, neutralizing anti-interferon-γ autoantibody was found in her serum, which was compatible with the scenario of adult-onset immunodeficiency.
format Online
Article
Text
id pubmed-9324542
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93245422022-07-27 Periocular Infection of Mycobacterium avium Complex in a Patient with Interferon-γ Autoantibodies: A Case Report Lo, Tzu-Hui Tsai, Tou-Yuan Wang, Lih-Shinn Huang, Tzu-Lun Chen, Nancy Medicina (Kaunas) Case Report The neutralizing anti-interferon-γ autoantibody (nAIGA)-associated immunodeficiency is an emerging entity frequently associated with the nontuberculosis mycobacterium (NTM) infection and other opportunistic infections. We present a female patient with a mysterious periocular Mycobacterium avium complex (MAC) infection, accompanied by sequential opportunistic infections including Salmollelosis and herpes zoster infection. Her condition stabilized after long-term antimycobacterial treatment. Nevertheless, neutralizing anti-interferon-γ autoantibody was found in her serum, which was compatible with the scenario of adult-onset immunodeficiency. MDPI 2022-06-24 /pmc/articles/PMC9324542/ /pubmed/35888565 http://dx.doi.org/10.3390/medicina58070846 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Lo, Tzu-Hui
Tsai, Tou-Yuan
Wang, Lih-Shinn
Huang, Tzu-Lun
Chen, Nancy
Periocular Infection of Mycobacterium avium Complex in a Patient with Interferon-γ Autoantibodies: A Case Report
title Periocular Infection of Mycobacterium avium Complex in a Patient with Interferon-γ Autoantibodies: A Case Report
title_full Periocular Infection of Mycobacterium avium Complex in a Patient with Interferon-γ Autoantibodies: A Case Report
title_fullStr Periocular Infection of Mycobacterium avium Complex in a Patient with Interferon-γ Autoantibodies: A Case Report
title_full_unstemmed Periocular Infection of Mycobacterium avium Complex in a Patient with Interferon-γ Autoantibodies: A Case Report
title_short Periocular Infection of Mycobacterium avium Complex in a Patient with Interferon-γ Autoantibodies: A Case Report
title_sort periocular infection of mycobacterium avium complex in a patient with interferon-γ autoantibodies: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324542/
https://www.ncbi.nlm.nih.gov/pubmed/35888565
http://dx.doi.org/10.3390/medicina58070846
work_keys_str_mv AT lotzuhui periocularinfectionofmycobacteriumaviumcomplexinapatientwithinterferongautoantibodiesacasereport
AT tsaitouyuan periocularinfectionofmycobacteriumaviumcomplexinapatientwithinterferongautoantibodiesacasereport
AT wanglihshinn periocularinfectionofmycobacteriumaviumcomplexinapatientwithinterferongautoantibodiesacasereport
AT huangtzulun periocularinfectionofmycobacteriumaviumcomplexinapatientwithinterferongautoantibodiesacasereport
AT chennancy periocularinfectionofmycobacteriumaviumcomplexinapatientwithinterferongautoantibodiesacasereport

Ejemplares similares