Cargando…

Uterus: A Unique Stem Cell Reservoir Able to Support Cardiac Repair via Crosstalk among Uterus, Heart, and Bone Marrow

Clinical evidence suggests that the prevalence of cardiac disease is lower in premenopausal women compared to postmenopausal women and men. Although multiple factors contribute to this difference, uterine stem cells may be a major factor, as a high abundance of these cells are present in the uterus....

Descripción completa

Detalles Bibliográficos
Autores principales: Ludke, Ana, Hatta, Kota, Yao, Alina, Li, Ren-Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324611/
https://www.ncbi.nlm.nih.gov/pubmed/35883625
http://dx.doi.org/10.3390/cells11142182
_version_ 1784756850368970752
author Ludke, Ana
Hatta, Kota
Yao, Alina
Li, Ren-Ke
author_facet Ludke, Ana
Hatta, Kota
Yao, Alina
Li, Ren-Ke
author_sort Ludke, Ana
collection PubMed
description Clinical evidence suggests that the prevalence of cardiac disease is lower in premenopausal women compared to postmenopausal women and men. Although multiple factors contribute to this difference, uterine stem cells may be a major factor, as a high abundance of these cells are present in the uterus. Uterine-derived stem cells have been reported in several studies as being able to contribute to cardiac neovascularization after injury. However, our studies uniquely show the presence of an “utero-cardiac axis”, in which uterine stem cells are able to home to cardiac tissue to promote tissue repair. Additionally, we raise the possibility of a triangular relationship among the bone marrow, uterus, and heart. In this review, we discuss the exchange of stem cells across different organs, focusing on the relationship that exists between the heart, uterus, and bone marrow. We present increasing evidence for the existence of an utero-cardiac axis, in which the uterus serves as a reservoir for cardiac reparative stem cells, similar to the bone marrow. These cells, in turn, are able to migrate to the heart in response to injury to promote healing.
format Online
Article
Text
id pubmed-9324611
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93246112022-07-27 Uterus: A Unique Stem Cell Reservoir Able to Support Cardiac Repair via Crosstalk among Uterus, Heart, and Bone Marrow Ludke, Ana Hatta, Kota Yao, Alina Li, Ren-Ke Cells Review Clinical evidence suggests that the prevalence of cardiac disease is lower in premenopausal women compared to postmenopausal women and men. Although multiple factors contribute to this difference, uterine stem cells may be a major factor, as a high abundance of these cells are present in the uterus. Uterine-derived stem cells have been reported in several studies as being able to contribute to cardiac neovascularization after injury. However, our studies uniquely show the presence of an “utero-cardiac axis”, in which uterine stem cells are able to home to cardiac tissue to promote tissue repair. Additionally, we raise the possibility of a triangular relationship among the bone marrow, uterus, and heart. In this review, we discuss the exchange of stem cells across different organs, focusing on the relationship that exists between the heart, uterus, and bone marrow. We present increasing evidence for the existence of an utero-cardiac axis, in which the uterus serves as a reservoir for cardiac reparative stem cells, similar to the bone marrow. These cells, in turn, are able to migrate to the heart in response to injury to promote healing. MDPI 2022-07-13 /pmc/articles/PMC9324611/ /pubmed/35883625 http://dx.doi.org/10.3390/cells11142182 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ludke, Ana
Hatta, Kota
Yao, Alina
Li, Ren-Ke
Uterus: A Unique Stem Cell Reservoir Able to Support Cardiac Repair via Crosstalk among Uterus, Heart, and Bone Marrow
title Uterus: A Unique Stem Cell Reservoir Able to Support Cardiac Repair via Crosstalk among Uterus, Heart, and Bone Marrow
title_full Uterus: A Unique Stem Cell Reservoir Able to Support Cardiac Repair via Crosstalk among Uterus, Heart, and Bone Marrow
title_fullStr Uterus: A Unique Stem Cell Reservoir Able to Support Cardiac Repair via Crosstalk among Uterus, Heart, and Bone Marrow
title_full_unstemmed Uterus: A Unique Stem Cell Reservoir Able to Support Cardiac Repair via Crosstalk among Uterus, Heart, and Bone Marrow
title_short Uterus: A Unique Stem Cell Reservoir Able to Support Cardiac Repair via Crosstalk among Uterus, Heart, and Bone Marrow
title_sort uterus: a unique stem cell reservoir able to support cardiac repair via crosstalk among uterus, heart, and bone marrow
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324611/
https://www.ncbi.nlm.nih.gov/pubmed/35883625
http://dx.doi.org/10.3390/cells11142182
work_keys_str_mv AT ludkeana uterusauniquestemcellreservoirabletosupportcardiacrepairviacrosstalkamonguterusheartandbonemarrow
AT hattakota uterusauniquestemcellreservoirabletosupportcardiacrepairviacrosstalkamonguterusheartandbonemarrow
AT yaoalina uterusauniquestemcellreservoirabletosupportcardiacrepairviacrosstalkamonguterusheartandbonemarrow
AT lirenke uterusauniquestemcellreservoirabletosupportcardiacrepairviacrosstalkamonguterusheartandbonemarrow