Cargando…

Opportunities and Challenges for In Silico Drug Discovery at Delta Opioid Receptors

The delta opioid receptor is a Gi-protein-coupled receptor (GPCR) with a broad expression pattern both in the central nervous system and the body. The receptor has been investigated as a potential target for a multitude of significant diseases including migraine, alcohol use disorder, ischemia, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meqbil, Yazan J., van Rijn, Richard M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324648/ https://www.ncbi.nlm.nih.gov/pubmed/35890173 http://dx.doi.org/10.3390/ph15070873

Ejemplares similares

Identification of a Novel Delta Opioid Receptor Agonist Chemotype with Potential Negative Allosteric Modulator Capabilities
por: Meqbil, Yazan J., et al.
Publicado: (2021)

Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery II
por: Van Rijn, Richard M., et al.
Publicado: (2022)

Engineering Quick- and Long-acting Naloxone Delivery Systems for Treating Opioid Overdose
por: Sharifi, Farrokh, et al.
Publicado: (2021)

ClickArr: a novel, high-throughput assay for evaluating β-arrestin isoform recruitment
por: French, Alexander R., et al.
Publicado: (2023)

Anti-Analgesic Effect of the Mu/Delta Opioid Receptor Heteromer Revealed by Ligand-Biased Antagonism
por: Milan-Lobo, Laura, et al.
Publicado: (2013)

Deuterium in drug discovery: progress, opportunities and challenges
por: Di Martino, Rita Maria Concetta, et al.
Publicado: (2023)

The Role of AI in Drug Discovery: Challenges, Opportunities, and Strategies
por: Blanco-González, Alexandre, et al.
Publicado: (2023)

The Opportunities and Challenges of Peroxisome Proliferator-Activated Receptors Ligands in Clinical Drug Discovery and Development
por: Hong, Fan, et al.
Publicado: (2018)

Exploration of beta-arrestin isoform signaling pathways in delta opioid receptor agonist-induced convulsions
por: Blaine, Arryn T., et al.
Publicado: (2022)

Discovery of small molecule cancer drugs: Successes, challenges and opportunities
por: Hoelder, Swen, et al.
Publicado: (2012)

Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery
por: Waman, Vaishali P., et al.
Publicado: (2019)

An Emerging Role for the Delta Opioid Receptor in the Regulation of Mu Opioid Receptor Function
por: Rozenfeld, Raphael, et al.
Publicado: (2007)

Opioid use disorder and treatment: challenges and opportunities
por: Hoffman, Kim A., et al.
Publicado: (2019)

Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery
por: Spetea, Mariana, et al.
Publicado: (2020)

“Omics”-Informed Drug and Biomarker Discovery: Opportunities, Challenges and Future Perspectives
por: Matthews, Holly, et al.
Publicado: (2016)

An Update on CFTR Drug Discovery: Opportunities and Challenges
por: D’Ursi, Pasqualina, et al.
Publicado: (2022)

AI in drug discovery: Applications, opportunities, and challenges
por: Bittner, Martin-Immanuel, et al.
Publicado: (2022)

Delta Opioid Receptor and Its Peptide: A Receptor-Ligand Neuroprotection
por: Staples, Meaghan, et al.
Publicado: (2013)

μ-opioid receptor agonists and psychedelics: pharmacological opportunities and challenges
por: Salinsky, Leah M., et al.
Publicado: (2023)

Discovery of Novel Delta Opioid Receptor (DOR) Inverse Agonist and Irreversible (Non-Competitive) Antagonists
por: Tanguturi, Parthasaradhireddy, et al.
Publicado: (2021)

Discovery of the First Small-Molecule Opioid Pan Antagonist with Nanomolar Affinity at Mu, Delta, Kappa, and Nociceptin Opioid Receptors
por: Zaveri, Nurulain T., et al.
Publicado: (2015)

In Silico Strategies in Tuberculosis Drug Discovery
por: Macalino, Stephani Joy Y., et al.
Publicado: (2020)

Molecular Perspectives for mu/delta Opioid Receptor Heteromers as Distinct, Functional Receptors
por: Ong, Edmund W., et al.
Publicado: (2014)

Forebrain delta opioid receptors regulate the response of delta agonist in models of migraine and opioid-induced hyperalgesia
por: Dripps, Isaac J., et al.
Publicado: (2020)

Drug-Like Protein–Protein Interaction Modulators: Challenges and Opportunities for Drug Discovery and Chemical Biology
por: Villoutreix, Bruno O, et al.
Publicado: (2014)

Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development
por: Biber, Knut, et al.
Publicado: (2019)

Pain Perception and the Opioid Receptor Delta 1
por: Hilgemeier, Adam T, et al.
Publicado: (2018)

Peptidomimetics and Their Applications for Opioid Peptide Drug Discovery
por: Lee, Yeon Sun
Publicado: (2022)

In silico pharmacology for drug discovery: applications to targets and beyond
por: Ekins, S, et al.
Publicado: (2007)

Perspective on the challenges and opportunities of accelerating drug discovery with artificial intelligence
por: Santa Maria, John P., et al.
Publicado: (2023)

Emerging strategies on in silico drug development against COVID-19: challenges and opportunities
por: Yadav, Manisha, et al.
Publicado: (2020)

The Meta-Position of Phe(4) in Leu-Enkephalin Regulates Potency, Selectivity, Functional Activity, and Signaling Bias at the Delta and Mu Opioid Receptors
por: Cassell, Robert J., et al.
Publicado: (2019)

Drug Discovery Opportunities and Challenges at G Protein Coupled Receptors for Long Chain Free Fatty Acids
por: Holliday, Nicholas D., et al.
Publicado: (2012)

Drug discovery in ophthalmology: past success, present challenges, and future opportunities
por: Gower, Nicholas J. D., et al.
Publicado: (2016)

Drug-drug cocrystals: Opportunities and challenges
por: Wang, Xiaojuan, et al.
Publicado: (2021)

Natural products in drug discovery: advances and opportunities
por: Atanasov, Atanas G., et al.
Publicado: (2021)

Discovery of 7-Azanorbornane-Based Dual Agonists for the Delta and Kappa Opioid Receptors through an In Situ Screening Protocol
por: Karaki, Fumika, et al.
Publicado: (2023)

The Changing Opioid Crisis: development, challenges and opportunities
por: Volkow, Nora D., et al.
Publicado: (2020)

Delta Opioid Receptors: The Link between Exercise and Cardioprotection
por: Borges, Juliana P., et al.
Publicado: (2014)

The Delta-Opioid Receptor; a Target for the Treatment of Pain
por: Quirion, Béatrice, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_lv5jv23fkr2b4g36tvd33am3v3