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Risk Factors for Lung Cancer in the Province of Lecce: Results from the PROTOS Case–Control Study in Salento (Southern Italy)
In the province of Lecce (southern Italy), a higher incidence of lung cancer (LC) among men compared to regional and national data was reported. In a sub-area in the center of the province (cluster area), the incidence and mortality for LC was even higher. PROTOS is a case–control study aimed at inv...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324751/ https://www.ncbi.nlm.nih.gov/pubmed/35886627 http://dx.doi.org/10.3390/ijerph19148775 |
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author | Minichilli, Fabrizio Gorini, Francesca De Filippis, Giovanni Bustaffa, Elisa Raho, Anna Maria Melcarne, Anna Quarta, Fabrizio Maggiore, Giuseppe Idolo, Adele Serio, Francesca Grassi, Tiziana Bagordo, Francesco Castorini, Idelberto Francesco Imbriani, Giovanni Bianchi, Fabrizio Piscitelli, Prisco |
author_facet | Minichilli, Fabrizio Gorini, Francesca De Filippis, Giovanni Bustaffa, Elisa Raho, Anna Maria Melcarne, Anna Quarta, Fabrizio Maggiore, Giuseppe Idolo, Adele Serio, Francesca Grassi, Tiziana Bagordo, Francesco Castorini, Idelberto Francesco Imbriani, Giovanni Bianchi, Fabrizio Piscitelli, Prisco |
author_sort | Minichilli, Fabrizio |
collection | PubMed |
description | In the province of Lecce (southern Italy), a higher incidence of lung cancer (LC) among men compared to regional and national data was reported. In a sub-area in the center of the province (cluster area), the incidence and mortality for LC was even higher. PROTOS is a case–control study aimed at investigating possible risk factors for LC in the province area. A total of 442 patients with LC and 1326 controls matched by sex and age living in the province of Lecce for at least 10 years were enrolled and georeferenced; they filled in a questionnaire with their personal information and exposures. For each risk factor, an Odds Ratio adjusted for all the other variables was calculated. The risk of LC increased with excessive use of alcohol in women, for those subjects with a family cancer history, for each increase in pack/year of cigarettes, for men more exposed considering the industrial district in the cluster area, and for those using pesticides in agriculture without wearing personal protective equipment. The higher incidence of adenocarcinoma in both sexes suggests that, in addition to cigarette smoking, concurrent exposures to other environmental, occupational, and life-style factors may play a role in increased cancer risk and should be more deeply explored. |
format | Online Article Text |
id | pubmed-9324751 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93247512022-07-27 Risk Factors for Lung Cancer in the Province of Lecce: Results from the PROTOS Case–Control Study in Salento (Southern Italy) Minichilli, Fabrizio Gorini, Francesca De Filippis, Giovanni Bustaffa, Elisa Raho, Anna Maria Melcarne, Anna Quarta, Fabrizio Maggiore, Giuseppe Idolo, Adele Serio, Francesca Grassi, Tiziana Bagordo, Francesco Castorini, Idelberto Francesco Imbriani, Giovanni Bianchi, Fabrizio Piscitelli, Prisco Int J Environ Res Public Health Article In the province of Lecce (southern Italy), a higher incidence of lung cancer (LC) among men compared to regional and national data was reported. In a sub-area in the center of the province (cluster area), the incidence and mortality for LC was even higher. PROTOS is a case–control study aimed at investigating possible risk factors for LC in the province area. A total of 442 patients with LC and 1326 controls matched by sex and age living in the province of Lecce for at least 10 years were enrolled and georeferenced; they filled in a questionnaire with their personal information and exposures. For each risk factor, an Odds Ratio adjusted for all the other variables was calculated. The risk of LC increased with excessive use of alcohol in women, for those subjects with a family cancer history, for each increase in pack/year of cigarettes, for men more exposed considering the industrial district in the cluster area, and for those using pesticides in agriculture without wearing personal protective equipment. The higher incidence of adenocarcinoma in both sexes suggests that, in addition to cigarette smoking, concurrent exposures to other environmental, occupational, and life-style factors may play a role in increased cancer risk and should be more deeply explored. MDPI 2022-07-19 /pmc/articles/PMC9324751/ /pubmed/35886627 http://dx.doi.org/10.3390/ijerph19148775 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Minichilli, Fabrizio Gorini, Francesca De Filippis, Giovanni Bustaffa, Elisa Raho, Anna Maria Melcarne, Anna Quarta, Fabrizio Maggiore, Giuseppe Idolo, Adele Serio, Francesca Grassi, Tiziana Bagordo, Francesco Castorini, Idelberto Francesco Imbriani, Giovanni Bianchi, Fabrizio Piscitelli, Prisco Risk Factors for Lung Cancer in the Province of Lecce: Results from the PROTOS Case–Control Study in Salento (Southern Italy) |
title | Risk Factors for Lung Cancer in the Province of Lecce: Results from the PROTOS Case–Control Study in Salento (Southern Italy) |
title_full | Risk Factors for Lung Cancer in the Province of Lecce: Results from the PROTOS Case–Control Study in Salento (Southern Italy) |
title_fullStr | Risk Factors for Lung Cancer in the Province of Lecce: Results from the PROTOS Case–Control Study in Salento (Southern Italy) |
title_full_unstemmed | Risk Factors for Lung Cancer in the Province of Lecce: Results from the PROTOS Case–Control Study in Salento (Southern Italy) |
title_short | Risk Factors for Lung Cancer in the Province of Lecce: Results from the PROTOS Case–Control Study in Salento (Southern Italy) |
title_sort | risk factors for lung cancer in the province of lecce: results from the protos case–control study in salento (southern italy) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324751/ https://www.ncbi.nlm.nih.gov/pubmed/35886627 http://dx.doi.org/10.3390/ijerph19148775 |
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