Evolutionary adaptation highlights the interconnection of fatty acids, sunlight, inflammation and epithelial adhesion

Gene variants that influence human biology today reflect thousands of years of evolution. Genetic effects on infant health are a major point of selective pressure, given that childhood survival is essential to evolutionary success. Knowledge of this evolutionary history can have implications for pae...

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Detalles Bibliográficos
Autores principales: Hlusko, Leslea J., McNelis, Madeline G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Mini Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324807/
https://www.ncbi.nlm.nih.gov/pubmed/35416313
http://dx.doi.org/10.1111/apa.16358
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author Hlusko, Leslea J.
McNelis, Madeline G.
author_facet Hlusko, Leslea J.
McNelis, Madeline G.
author_sort Hlusko, Leslea J.
collection PubMed
description Gene variants that influence human biology today reflect thousands of years of evolution. Genetic effects on infant health are a major point of selective pressure, given that childhood survival is essential to evolutionary success. Knowledge of this evolutionary history can have implications for paediatric research. CONCLUSION: An episode of human adaptation to the extremely low ultraviolet radiation environment of the Arctic 20,000 years ago implicates the Ectodysplasin A Receptor (EDAR) and the Fatty Acid Desaturases (FADS) in human lactation and epithelial inflammation.
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spelling pubmed-93248072022-07-30 Evolutionary adaptation highlights the interconnection of fatty acids, sunlight, inflammation and epithelial adhesion Hlusko, Leslea J. McNelis, Madeline G. Acta Paediatr Mini Reviews Gene variants that influence human biology today reflect thousands of years of evolution. Genetic effects on infant health are a major point of selective pressure, given that childhood survival is essential to evolutionary success. Knowledge of this evolutionary history can have implications for paediatric research. CONCLUSION: An episode of human adaptation to the extremely low ultraviolet radiation environment of the Arctic 20,000 years ago implicates the Ectodysplasin A Receptor (EDAR) and the Fatty Acid Desaturases (FADS) in human lactation and epithelial inflammation. John Wiley and Sons Inc. 2022-04-22 2022-07 /pmc/articles/PMC9324807/ /pubmed/35416313 http://dx.doi.org/10.1111/apa.16358 Text en ©2022 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Mini Reviews
Hlusko, Leslea J.
McNelis, Madeline G.
Evolutionary adaptation highlights the interconnection of fatty acids, sunlight, inflammation and epithelial adhesion
title Evolutionary adaptation highlights the interconnection of fatty acids, sunlight, inflammation and epithelial adhesion
title_full Evolutionary adaptation highlights the interconnection of fatty acids, sunlight, inflammation and epithelial adhesion
title_fullStr Evolutionary adaptation highlights the interconnection of fatty acids, sunlight, inflammation and epithelial adhesion
title_full_unstemmed Evolutionary adaptation highlights the interconnection of fatty acids, sunlight, inflammation and epithelial adhesion
title_short Evolutionary adaptation highlights the interconnection of fatty acids, sunlight, inflammation and epithelial adhesion
title_sort evolutionary adaptation highlights the interconnection of fatty acids, sunlight, inflammation and epithelial adhesion
topic Mini Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9324807/
https://www.ncbi.nlm.nih.gov/pubmed/35416313
http://dx.doi.org/10.1111/apa.16358
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