A Slice‐Low‐Rank Plus Sparse (slice‐L + S) Reconstruction Method for k‐t Undersampled Multiband First‐Pass Myocardial Perfusion MRI

PURPOSE: The synergistic use of k‐t undersampling and multiband (MB) imaging has the potential to provide extended slice coverage and high spatial resolution for first‐pass perfusion MRI. The low‐rank plus sparse (L + S) model has shown excellent performance for accelerating single‐band (SB) perfusion MRI. METHODS: A MB data consistency method employing ESPIRiT maps and through‐plane coil information was developed. This data consistency method was combined with the temporal L + S constraint to form the slice‐L + S method. Slice‐L + S was compared to SB L + S and the sequential operations of split slice‐GRAPPA and SB L + S (seq‐SG‐L + S) using synthetic data formed from multislice SB images. Prospectively k‐t undersampled MB data were also acquired and reconstructed using seq‐SG‐L + S and slice‐L + S. RESULTS: Using synthetic data with total acceleration rates of 6–12, slice‐L + S outperformed SB L + S and seq‐SG‐L + S (N = 7 subjects) with respect to normalized RMSE and the structural similarity index (P < 0.05 for both). For the specific case with MB factor = 3 and rate 3 undersampling, or for SB imaging with rate 9 undersampling (N = 7 subjects), the normalized RMSE values were 0.037 ± 0.007, 0.042 ± 0.005, and 0.031 ± 0.004; and the structural similarity index values were 0.88 ± 0.03, 0.85 ± 0.03, and 0.89 ± 0.02 for SB L + S, seq‐SG‐L + S, and slice‐L + S, respectively (P < 0.05 for both). For prospectively undersampled MB data, slice‐L + S provided better image quality than seq‐SG‐L + S for rate 6 (N = 7) and rate 9 acceleration (N = 7) as scored by blinded experts. CONCLUSION: Slice‐L + S outperformed SB‐L + S and seq‐SG‐L + S and provides 9 slice coverage of the left ventricle with a spatial resolution of 1.5 mm × 1.5 mm with good image quality.