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Outcome and Midterm Survival after Heart Transplantation Is Independent from Donor Length of Stay in the Intensive Care Unit

Prolonged treatment of organ donors in the intensive care unit (ICU) may be associated with complications influencing the outcome after heart transplantation (HTx). We therefore aim to explore the potential impact of the donor length of stay (LOS) in the ICU on outcomes in our cohort. We included al...

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Autores principales: Oehler, Daniel, Böttger, Charlotte, Immohr, Moritz Benjamin, Bruno, Raphael Romano, Haschemi, Jafer, Scheiber, Daniel, Horn, Patrick, Aubin, Hug, Tudorache, Igor, Westenfeld, Ralf, Akhyari, Payam, Kelm, Malte, Lichtenberg, Artur, Boeken, Udo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325071/
https://www.ncbi.nlm.nih.gov/pubmed/35888141
http://dx.doi.org/10.3390/life12071053
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author Oehler, Daniel
Böttger, Charlotte
Immohr, Moritz Benjamin
Bruno, Raphael Romano
Haschemi, Jafer
Scheiber, Daniel
Horn, Patrick
Aubin, Hug
Tudorache, Igor
Westenfeld, Ralf
Akhyari, Payam
Kelm, Malte
Lichtenberg, Artur
Boeken, Udo
author_facet Oehler, Daniel
Böttger, Charlotte
Immohr, Moritz Benjamin
Bruno, Raphael Romano
Haschemi, Jafer
Scheiber, Daniel
Horn, Patrick
Aubin, Hug
Tudorache, Igor
Westenfeld, Ralf
Akhyari, Payam
Kelm, Malte
Lichtenberg, Artur
Boeken, Udo
author_sort Oehler, Daniel
collection PubMed
description Prolonged treatment of organ donors in the intensive care unit (ICU) may be associated with complications influencing the outcome after heart transplantation (HTx). We therefore aim to explore the potential impact of the donor length of stay (LOS) in the ICU on outcomes in our cohort. We included all patients undergoing HTx in our center between September 2010 and April 2022 (n = 241). Recipients were divided around the median into three groups regarding their donor LOS in the ICU: 0 to 3 days (≤50th percentile, n = 92), 4 to 7 days (50th–75th percentile, n = 80), and ≥8 days (≥75th percentile, n = 69). Donor LOS in the ICU ranged between 0 and 155 days (median 4, IQR 3–8 days). No association between the LOS in the ICU and survival after HTx was observed (AUC for overall survival 0.514). Neither the Kaplan–Meier survival analysis up to 5 years after HTx (Log-Rank p = 0.789) nor group comparisons showed significant differences. Baseline recipient characteristics were comparable between the groups, while the donor baselines differed in some parameters, such as less cardiopulmonary resuscitation prior to HTx in those with a prolonged LOS. However, regarding the recipients’ peri- and postoperative parameters, the groups did not differ in all of the assessed parameters. Thus, in this retrospective analysis, although the donors differed in baseline parameters, the donor LOS in the ICU was not associated with altered recipient survival or outcome after HTx.
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spelling pubmed-93250712022-07-27 Outcome and Midterm Survival after Heart Transplantation Is Independent from Donor Length of Stay in the Intensive Care Unit Oehler, Daniel Böttger, Charlotte Immohr, Moritz Benjamin Bruno, Raphael Romano Haschemi, Jafer Scheiber, Daniel Horn, Patrick Aubin, Hug Tudorache, Igor Westenfeld, Ralf Akhyari, Payam Kelm, Malte Lichtenberg, Artur Boeken, Udo Life (Basel) Article Prolonged treatment of organ donors in the intensive care unit (ICU) may be associated with complications influencing the outcome after heart transplantation (HTx). We therefore aim to explore the potential impact of the donor length of stay (LOS) in the ICU on outcomes in our cohort. We included all patients undergoing HTx in our center between September 2010 and April 2022 (n = 241). Recipients were divided around the median into three groups regarding their donor LOS in the ICU: 0 to 3 days (≤50th percentile, n = 92), 4 to 7 days (50th–75th percentile, n = 80), and ≥8 days (≥75th percentile, n = 69). Donor LOS in the ICU ranged between 0 and 155 days (median 4, IQR 3–8 days). No association between the LOS in the ICU and survival after HTx was observed (AUC for overall survival 0.514). Neither the Kaplan–Meier survival analysis up to 5 years after HTx (Log-Rank p = 0.789) nor group comparisons showed significant differences. Baseline recipient characteristics were comparable between the groups, while the donor baselines differed in some parameters, such as less cardiopulmonary resuscitation prior to HTx in those with a prolonged LOS. However, regarding the recipients’ peri- and postoperative parameters, the groups did not differ in all of the assessed parameters. Thus, in this retrospective analysis, although the donors differed in baseline parameters, the donor LOS in the ICU was not associated with altered recipient survival or outcome after HTx. MDPI 2022-07-14 /pmc/articles/PMC9325071/ /pubmed/35888141 http://dx.doi.org/10.3390/life12071053 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Oehler, Daniel
Böttger, Charlotte
Immohr, Moritz Benjamin
Bruno, Raphael Romano
Haschemi, Jafer
Scheiber, Daniel
Horn, Patrick
Aubin, Hug
Tudorache, Igor
Westenfeld, Ralf
Akhyari, Payam
Kelm, Malte
Lichtenberg, Artur
Boeken, Udo
Outcome and Midterm Survival after Heart Transplantation Is Independent from Donor Length of Stay in the Intensive Care Unit
title Outcome and Midterm Survival after Heart Transplantation Is Independent from Donor Length of Stay in the Intensive Care Unit
title_full Outcome and Midterm Survival after Heart Transplantation Is Independent from Donor Length of Stay in the Intensive Care Unit
title_fullStr Outcome and Midterm Survival after Heart Transplantation Is Independent from Donor Length of Stay in the Intensive Care Unit
title_full_unstemmed Outcome and Midterm Survival after Heart Transplantation Is Independent from Donor Length of Stay in the Intensive Care Unit
title_short Outcome and Midterm Survival after Heart Transplantation Is Independent from Donor Length of Stay in the Intensive Care Unit
title_sort outcome and midterm survival after heart transplantation is independent from donor length of stay in the intensive care unit
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325071/
https://www.ncbi.nlm.nih.gov/pubmed/35888141
http://dx.doi.org/10.3390/life12071053
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