Cargando…
Clinical Characteristics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Diagnosed in Patients with Long COVID
Background and Objectives: COVID-19 can be serious not only in the acute phase but also after the acute phase and some patients develop ME/CFS. There have been few studies on patients with long COVID in whom ME/CFS was diagnosed by physicians based on standardized criteria after examinations and exc...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325226/ https://www.ncbi.nlm.nih.gov/pubmed/35888568 http://dx.doi.org/10.3390/medicina58070850 |
_version_ | 1784756997047975936 |
---|---|
author | Tokumasu, Kazuki Honda, Hiroyuki Sunada, Naruhiko Sakurada, Yasue Matsuda, Yui Yamamoto, Koichiro Nakano, Yasuhiro Hasegawa, Toru Yamamoto, Yukichika Otsuka, Yuki Hagiya, Hideharu Kataoka, Hitomi Ueda, Keigo Otsuka, Fumio |
author_facet | Tokumasu, Kazuki Honda, Hiroyuki Sunada, Naruhiko Sakurada, Yasue Matsuda, Yui Yamamoto, Koichiro Nakano, Yasuhiro Hasegawa, Toru Yamamoto, Yukichika Otsuka, Yuki Hagiya, Hideharu Kataoka, Hitomi Ueda, Keigo Otsuka, Fumio |
author_sort | Tokumasu, Kazuki |
collection | PubMed |
description | Background and Objectives: COVID-19 can be serious not only in the acute phase but also after the acute phase and some patients develop ME/CFS. There have been few studies on patients with long COVID in whom ME/CFS was diagnosed by physicians based on standardized criteria after examinations and exclusion diagnosis and not based on only subjective symptoms. The purpose of this study was to elucidate the detailed characteristics of ME/CFS in patients with long COVID. Materials and Methods: A retrospective descriptive study was performed for patients who visited a COVID-19 aftercare clinic established in Okayama University Hospital during the period was from February 2021 to April 2022. Results: Clinical data were obtained from medical records for 281 patients, and 279 patients who met the definition of long COVID were included. The overall prevalence rate of ME/CFS diagnosed by three sets of ME/CFS criteria (Fukuda, Canadian and IOM criteria) was 16.8% (48.9% in male and 51.1% in females). The most frequent symptoms in ME/CFS patients were general fatigue and post-exertional malaise (89.4% of the patients), headache (34.0%), insomnia (23.4%), dysosmia (21.3%) and dysgeusia (19.1%). Dizziness, chest pain, insomnia and headache were characteristic symptoms related to ME/CFS. The male to female ratio in ME/CFS patients was equal in the present study, although ME/CFS was generally more common in women in previous studies. Given that patients with ME/CFS had more severe conditions in the acute phase of COVID-19, the severity of the acute infectious state might be involved in the pathophysiology of ME/CFS. Conclusions: The prevalence rate of ME/CFS and the characteristic sequelae in the long COVID condition were revealed in this study. |
format | Online Article Text |
id | pubmed-9325226 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93252262022-07-27 Clinical Characteristics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Diagnosed in Patients with Long COVID Tokumasu, Kazuki Honda, Hiroyuki Sunada, Naruhiko Sakurada, Yasue Matsuda, Yui Yamamoto, Koichiro Nakano, Yasuhiro Hasegawa, Toru Yamamoto, Yukichika Otsuka, Yuki Hagiya, Hideharu Kataoka, Hitomi Ueda, Keigo Otsuka, Fumio Medicina (Kaunas) Article Background and Objectives: COVID-19 can be serious not only in the acute phase but also after the acute phase and some patients develop ME/CFS. There have been few studies on patients with long COVID in whom ME/CFS was diagnosed by physicians based on standardized criteria after examinations and exclusion diagnosis and not based on only subjective symptoms. The purpose of this study was to elucidate the detailed characteristics of ME/CFS in patients with long COVID. Materials and Methods: A retrospective descriptive study was performed for patients who visited a COVID-19 aftercare clinic established in Okayama University Hospital during the period was from February 2021 to April 2022. Results: Clinical data were obtained from medical records for 281 patients, and 279 patients who met the definition of long COVID were included. The overall prevalence rate of ME/CFS diagnosed by three sets of ME/CFS criteria (Fukuda, Canadian and IOM criteria) was 16.8% (48.9% in male and 51.1% in females). The most frequent symptoms in ME/CFS patients were general fatigue and post-exertional malaise (89.4% of the patients), headache (34.0%), insomnia (23.4%), dysosmia (21.3%) and dysgeusia (19.1%). Dizziness, chest pain, insomnia and headache were characteristic symptoms related to ME/CFS. The male to female ratio in ME/CFS patients was equal in the present study, although ME/CFS was generally more common in women in previous studies. Given that patients with ME/CFS had more severe conditions in the acute phase of COVID-19, the severity of the acute infectious state might be involved in the pathophysiology of ME/CFS. Conclusions: The prevalence rate of ME/CFS and the characteristic sequelae in the long COVID condition were revealed in this study. MDPI 2022-06-25 /pmc/articles/PMC9325226/ /pubmed/35888568 http://dx.doi.org/10.3390/medicina58070850 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tokumasu, Kazuki Honda, Hiroyuki Sunada, Naruhiko Sakurada, Yasue Matsuda, Yui Yamamoto, Koichiro Nakano, Yasuhiro Hasegawa, Toru Yamamoto, Yukichika Otsuka, Yuki Hagiya, Hideharu Kataoka, Hitomi Ueda, Keigo Otsuka, Fumio Clinical Characteristics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Diagnosed in Patients with Long COVID |
title | Clinical Characteristics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Diagnosed in Patients with Long COVID |
title_full | Clinical Characteristics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Diagnosed in Patients with Long COVID |
title_fullStr | Clinical Characteristics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Diagnosed in Patients with Long COVID |
title_full_unstemmed | Clinical Characteristics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Diagnosed in Patients with Long COVID |
title_short | Clinical Characteristics of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Diagnosed in Patients with Long COVID |
title_sort | clinical characteristics of myalgic encephalomyelitis/chronic fatigue syndrome (me/cfs) diagnosed in patients with long covid |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325226/ https://www.ncbi.nlm.nih.gov/pubmed/35888568 http://dx.doi.org/10.3390/medicina58070850 |
work_keys_str_mv | AT tokumasukazuki clinicalcharacteristicsofmyalgicencephalomyelitischronicfatiguesyndromemecfsdiagnosedinpatientswithlongcovid AT hondahiroyuki clinicalcharacteristicsofmyalgicencephalomyelitischronicfatiguesyndromemecfsdiagnosedinpatientswithlongcovid AT sunadanaruhiko clinicalcharacteristicsofmyalgicencephalomyelitischronicfatiguesyndromemecfsdiagnosedinpatientswithlongcovid AT sakuradayasue clinicalcharacteristicsofmyalgicencephalomyelitischronicfatiguesyndromemecfsdiagnosedinpatientswithlongcovid AT matsudayui clinicalcharacteristicsofmyalgicencephalomyelitischronicfatiguesyndromemecfsdiagnosedinpatientswithlongcovid AT yamamotokoichiro clinicalcharacteristicsofmyalgicencephalomyelitischronicfatiguesyndromemecfsdiagnosedinpatientswithlongcovid AT nakanoyasuhiro clinicalcharacteristicsofmyalgicencephalomyelitischronicfatiguesyndromemecfsdiagnosedinpatientswithlongcovid AT hasegawatoru clinicalcharacteristicsofmyalgicencephalomyelitischronicfatiguesyndromemecfsdiagnosedinpatientswithlongcovid AT yamamotoyukichika clinicalcharacteristicsofmyalgicencephalomyelitischronicfatiguesyndromemecfsdiagnosedinpatientswithlongcovid AT otsukayuki clinicalcharacteristicsofmyalgicencephalomyelitischronicfatiguesyndromemecfsdiagnosedinpatientswithlongcovid AT hagiyahideharu clinicalcharacteristicsofmyalgicencephalomyelitischronicfatiguesyndromemecfsdiagnosedinpatientswithlongcovid AT kataokahitomi clinicalcharacteristicsofmyalgicencephalomyelitischronicfatiguesyndromemecfsdiagnosedinpatientswithlongcovid AT uedakeigo clinicalcharacteristicsofmyalgicencephalomyelitischronicfatiguesyndromemecfsdiagnosedinpatientswithlongcovid AT otsukafumio clinicalcharacteristicsofmyalgicencephalomyelitischronicfatiguesyndromemecfsdiagnosedinpatientswithlongcovid |