Effect of Cyclosporin A and Impact of Dose Staggering on OATP1B1/1B3 Endogenous Substrates and Drug Probes for Assessing Clinical Drug Interactions

This study was designed to assess the quantitative performance of endogenous biomarkers for organic anion transporting polypeptide (OATP) 1B1/1B3‐mediated drug‐drug interactions (DDIs). Ten healthy volunteers orally received OATP1B1/1B3 probe cocktail (0.2 mg pitavastatin, 1 mg rosuvastatin, and 2 m...

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Detalles Bibliográficos
Autores principales: Mochizuki, Tatsuki, Zamek‐Gliszczynski, Maciej J., Yoshida, Kenta, Mao, Jialin, Taskar, Kunal, Hirabayashi, Hideki, Chu, Xiaoyan, Lai, Yurong, Takashima, Tadayuki, Rockich, Kevin, Yamaura, Yoshiyuki, Fujiwara, Kaku, Mizuno, Tadahaya, Maeda, Kazuya, Furihata, Kenichi, Sugiyama, Yuichi, Kusuhara, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325410/
https://www.ncbi.nlm.nih.gov/pubmed/35292967
http://dx.doi.org/10.1002/cpt.2584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325410/
https://www.ncbi.nlm.nih.gov/pubmed/35292967
http://dx.doi.org/10.1002/cpt.2584

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