Cargando…
Molecular interactions between the intestinal microbiota and the host
The intestine is the most densely colonized region of the body, inhabited by a diverse community of microbes. The functional significance of the intestinal microbiota is not yet fully understood, but it is known that the microbiota is implicated in numerous physiological processes of the host, such...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325447/ https://www.ncbi.nlm.nih.gov/pubmed/35403275 http://dx.doi.org/10.1111/mmi.14905 |
_version_ | 1784757054185930752 |
---|---|
author | Hertli, Salomé Zimmermann, Petra |
author_facet | Hertli, Salomé Zimmermann, Petra |
author_sort | Hertli, Salomé |
collection | PubMed |
description | The intestine is the most densely colonized region of the body, inhabited by a diverse community of microbes. The functional significance of the intestinal microbiota is not yet fully understood, but it is known that the microbiota is implicated in numerous physiological processes of the host, such as metabolism, nutrition, the immune system, and regulation of behavior and mood. This article reviews recent findings on how bacteria of the intestinal microbiota interact with the host. Microbiota‐microbiota and microbiota‐host interactions are mediated by direct cell contact and by metabolites either produced by bacteria or produced by the host or the environment and metabolized by bacteria. Among them are short‐chain fatty, including butyrate, propionate, and acetate. Other examples include polyamines, linoleic acid metabolites, tryptophan metabolites, trimethylamine‐N‐oxide, vitamins, and secondary bile acids. These metabolites are involved in regulating the cell cycle, neurobiological signaling, cholesterol and bile acid metabolism, immune responses, and responses to antioxidants. Understanding the host‐microbiota pathways and their modulation will allow the identification of individualized therapeutic targets for many diseases. This overview helps to facilitate and promote further research in this field. |
format | Online Article Text |
id | pubmed-9325447 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93254472022-07-30 Molecular interactions between the intestinal microbiota and the host Hertli, Salomé Zimmermann, Petra Mol Microbiol Micro Reviews The intestine is the most densely colonized region of the body, inhabited by a diverse community of microbes. The functional significance of the intestinal microbiota is not yet fully understood, but it is known that the microbiota is implicated in numerous physiological processes of the host, such as metabolism, nutrition, the immune system, and regulation of behavior and mood. This article reviews recent findings on how bacteria of the intestinal microbiota interact with the host. Microbiota‐microbiota and microbiota‐host interactions are mediated by direct cell contact and by metabolites either produced by bacteria or produced by the host or the environment and metabolized by bacteria. Among them are short‐chain fatty, including butyrate, propionate, and acetate. Other examples include polyamines, linoleic acid metabolites, tryptophan metabolites, trimethylamine‐N‐oxide, vitamins, and secondary bile acids. These metabolites are involved in regulating the cell cycle, neurobiological signaling, cholesterol and bile acid metabolism, immune responses, and responses to antioxidants. Understanding the host‐microbiota pathways and their modulation will allow the identification of individualized therapeutic targets for many diseases. This overview helps to facilitate and promote further research in this field. John Wiley and Sons Inc. 2022-04-25 2022-06 /pmc/articles/PMC9325447/ /pubmed/35403275 http://dx.doi.org/10.1111/mmi.14905 Text en © 2022 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Micro Reviews Hertli, Salomé Zimmermann, Petra Molecular interactions between the intestinal microbiota and the host |
title | Molecular interactions between the intestinal microbiota and the host |
title_full | Molecular interactions between the intestinal microbiota and the host |
title_fullStr | Molecular interactions between the intestinal microbiota and the host |
title_full_unstemmed | Molecular interactions between the intestinal microbiota and the host |
title_short | Molecular interactions between the intestinal microbiota and the host |
title_sort | molecular interactions between the intestinal microbiota and the host |
topic | Micro Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325447/ https://www.ncbi.nlm.nih.gov/pubmed/35403275 http://dx.doi.org/10.1111/mmi.14905 |
work_keys_str_mv | AT hertlisalome molecularinteractionsbetweentheintestinalmicrobiotaandthehost AT zimmermannpetra molecularinteractionsbetweentheintestinalmicrobiotaandthehost |