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The role and mechanism of noncoding RNAs in regulation of metabolic reprogramming in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Metabolic reprogramming is considered to be an important hallmark of cancer. Emerging studies have demonstrated that noncoding RNAs (ncRNAs) are closely associated with metabolic reprogramming of HCC. NcRNAs can directly...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325518/ https://www.ncbi.nlm.nih.gov/pubmed/35460073 http://dx.doi.org/10.1002/ijc.34040 |
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author | Liao, Wenwei Du, Jinpeng Wang, Zhen Feng, Qingbo Liao, Mingheng Liu, Huixian Yuan, Kefei Zeng, Yong |
author_facet | Liao, Wenwei Du, Jinpeng Wang, Zhen Feng, Qingbo Liao, Mingheng Liu, Huixian Yuan, Kefei Zeng, Yong |
author_sort | Liao, Wenwei |
collection | PubMed |
description | Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Metabolic reprogramming is considered to be an important hallmark of cancer. Emerging studies have demonstrated that noncoding RNAs (ncRNAs) are closely associated with metabolic reprogramming of HCC. NcRNAs can directly regulate the expressions or functions of metabolic enzymes or indirectly regulate the metabolism of HCC cells through some vital signaling pathways. Until now, the mechanisms of HCC development and progression remain largely unclear, and understanding the regulatory mechanism of ncRNAs on metabolic reprogramming of HCC may provide an important basis for breakthrough progress in the treatment of HCC. In this review, we summarize the ncRNAs involved in regulating metabolic reprogramming of HCC. Specifically, the regulatory roles of ncRNAs in glucose, lipid and amino acid metabolism are elaborated. In addition, we discuss the molecular mechanism of ncRNAs in regulation of metabolic reprogramming and possible therapeutic strategies that target the metabolism of cancer cells by modulating the expressions of specific ncRNAs. |
format | Online Article Text |
id | pubmed-9325518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93255182022-07-30 The role and mechanism of noncoding RNAs in regulation of metabolic reprogramming in hepatocellular carcinoma Liao, Wenwei Du, Jinpeng Wang, Zhen Feng, Qingbo Liao, Mingheng Liu, Huixian Yuan, Kefei Zeng, Yong Int J Cancer Review Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Metabolic reprogramming is considered to be an important hallmark of cancer. Emerging studies have demonstrated that noncoding RNAs (ncRNAs) are closely associated with metabolic reprogramming of HCC. NcRNAs can directly regulate the expressions or functions of metabolic enzymes or indirectly regulate the metabolism of HCC cells through some vital signaling pathways. Until now, the mechanisms of HCC development and progression remain largely unclear, and understanding the regulatory mechanism of ncRNAs on metabolic reprogramming of HCC may provide an important basis for breakthrough progress in the treatment of HCC. In this review, we summarize the ncRNAs involved in regulating metabolic reprogramming of HCC. Specifically, the regulatory roles of ncRNAs in glucose, lipid and amino acid metabolism are elaborated. In addition, we discuss the molecular mechanism of ncRNAs in regulation of metabolic reprogramming and possible therapeutic strategies that target the metabolism of cancer cells by modulating the expressions of specific ncRNAs. John Wiley & Sons, Inc. 2022-05-11 2022-08-01 /pmc/articles/PMC9325518/ /pubmed/35460073 http://dx.doi.org/10.1002/ijc.34040 Text en © 2022 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Review Liao, Wenwei Du, Jinpeng Wang, Zhen Feng, Qingbo Liao, Mingheng Liu, Huixian Yuan, Kefei Zeng, Yong The role and mechanism of noncoding RNAs in regulation of metabolic reprogramming in hepatocellular carcinoma |
title | The role and mechanism of noncoding RNAs in regulation of metabolic reprogramming in hepatocellular carcinoma |
title_full | The role and mechanism of noncoding RNAs in regulation of metabolic reprogramming in hepatocellular carcinoma |
title_fullStr | The role and mechanism of noncoding RNAs in regulation of metabolic reprogramming in hepatocellular carcinoma |
title_full_unstemmed | The role and mechanism of noncoding RNAs in regulation of metabolic reprogramming in hepatocellular carcinoma |
title_short | The role and mechanism of noncoding RNAs in regulation of metabolic reprogramming in hepatocellular carcinoma |
title_sort | role and mechanism of noncoding rnas in regulation of metabolic reprogramming in hepatocellular carcinoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325518/ https://www.ncbi.nlm.nih.gov/pubmed/35460073 http://dx.doi.org/10.1002/ijc.34040 |
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