Limited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors

Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability due to increased free radicals and reduced energy production. In pancreatic cancer cells a cytosolic metabolic enzyme, wild-type isocitrate dehydrogenase 1 (wtIDH1), enables adaptation to these conditions...

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Detalles Bibliográficos
Autores principales: Vaziri-Gohar, Ali, Cassel, Joel, Mohammed, Farheen S., Zarei, Mehrdad, Hue, Jonathan J., Hajihassani, Omid, Graor, Hallie J., Srikanth, Yellamelli V. V., Karim, Saadia A., Abbas, Ata, Prendergast, Erin, Chen, Vanessa, Katayama, Erryk S., Dukleska, Katerina, Khokhar, Imran, Andren, Anthony, Zhang, Li, Wu, Chunying, Erokwu, Bernadette, Flask, Chris A., Zarei, Mahsa, Wang, Rui, Rothermel, Luke D., Romani, Andrea M. P., Bowers, Jessica, Getts, Robert, Tatsuoka, Curtis, Morton, Jennifer P., Bederman, Ilya, Brunengraber, Henri, Lyssiotis, Costas A., Salvino, Joseph M., Brody, Jonathan R., Winter, Jordan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325670/
https://www.ncbi.nlm.nih.gov/pubmed/35681100
http://dx.doi.org/10.1038/s43018-022-00393-y

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