Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress

Triple-negative breast cancer (TNBC) has a poor clinical outcome, due to a lack of actionable therapeutic targets. Herein we define lysosomal acid lipase A (LIPA) as a viable molecular target in TNBC and identify a stereospecific small molecule (ERX-41) that binds LIPA. ERX-41 induces endoplasmic re...

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Detalles Bibliográficos
Autores principales: Liu, Xihui, Viswanadhapalli, Suryavathi, Kumar, Shourya, Lee, Tae-Kyung, Moore, Andrew, Ma, Shihong, Chen, Liping, Hsieh, Michael, Li, Mengxing, Sareddy, Gangadhara R., Parra, Karla, Blatt, Eliot B., Reese, Tanner C., Zhao, Yuting, Chang, Annabel, Yan, Hui, Xu, Zhenming, Pratap, Uday P., Liu, Zexuan, Roggero, Carlos M., Tan, Zhenqiu, Weintraub, Susan T., Peng, Yan, Tekmal, Rajeshwar R., Arteaga, Carlos L., Lippincott-Schwartz, Jennifer, Vadlamudi, Ratna K., Ahn, Jung-Mo, Raj, Ganesh V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325671/
https://www.ncbi.nlm.nih.gov/pubmed/35654861
http://dx.doi.org/10.1038/s43018-022-00389-8

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