Structural and mechanistic insights into the cleavage of clustered O-glycan patches-containing glycoproteins by mucinases of the human gut

Mucinases of human gut bacteria cleave peptide bonds in mucins strictly depending on the presence of neighboring O-glycans. The Akkermansia muciniphila AM0627 mucinase cleaves specifically in between contiguous (bis) O-glycans of defined truncated structures, suggesting that this enzyme may recogniz...

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Detalles Bibliográficos
Autores principales: Taleb, Víctor, Liao, Qinghua, Narimatsu, Yoshiki, García-García, Ana, Compañón, Ismael, Borges, Rafael Junqueira, González-Ramírez, Andrés Manuel, Corzana, Francisco, Clausen, Henrik, Rovira, Carme, Hurtado-Guerrero, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325726/
https://www.ncbi.nlm.nih.gov/pubmed/35882872
http://dx.doi.org/10.1038/s41467-022-32021-9

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