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The Cologne-Mecklenburg-Vorpommern DMEK Donor Study (COMEDOS) — design and review of the influence of donor characteristics on Descemet membrane endothelial keratoplasty (DMEK) outcome

BACKGROUND: Posterior lamellar keratoplasty and especially Descemet membrane endothelial keratoplasty (DMEK) are gaining interest worldwide. Little is known about the influence of donor factors on DMEK outcome. Here we provide an overview of the existing peer-reviewed literature on this topic and pr...

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Autores principales: Schrittenlocher, Silvia, Matthaei, Mario, Bachmann, Björn, Cursiefen, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325796/
https://www.ncbi.nlm.nih.gov/pubmed/35294636
http://dx.doi.org/10.1007/s00417-022-05594-w
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author Schrittenlocher, Silvia
Matthaei, Mario
Bachmann, Björn
Cursiefen, Claus
author_facet Schrittenlocher, Silvia
Matthaei, Mario
Bachmann, Björn
Cursiefen, Claus
author_sort Schrittenlocher, Silvia
collection PubMed
description BACKGROUND: Posterior lamellar keratoplasty and especially Descemet membrane endothelial keratoplasty (DMEK) are gaining interest worldwide. Little is known about the influence of donor factors on DMEK outcome. Here we provide an overview of the existing peer-reviewed literature on this topic and present the design of the upcoming cooperation study COMEDOS (Cologne-Mecklenburg-Vorpommern DMEK Donor Study). METHODS: A literature search of PubMed and MEDLINE was conducted to retrieve articles published between September 2013 and May 2021. Seventeen peer-reviewed articles were selected. Design and concept of the prospective COMEDOS are outlined. RESULTS: Main interest parameters were the donor diabetes mellitus status, age, and lens status. There is a large heterogeneity regarding the sample size, study design, and investigated parameters. There seems to be a consensus that younger donors are associated with tighter rolls, a more difficult preparation, and unfolding setting. Diabetic donors seem to increase the risk of tissue tearing due to adherences and result more frequently in preparation failure. The COMEDOS aims not only to analyze the diabetes status of the donor, but also to correlate all donor systemic comorbidities and their ophthalmologic history to the DMEK clinical outcome. Furthermore, a correlation of Descemet membrane lamella preparation and surgery outcome is planned. CONCLUSION: Currently, there is a lack of knowledge regarding the effect and impact of donor tissue characteristics on DMEK outcome and complications. An in-depth investigation is planned by the upcoming COMEDOS to close this knowledge gap. [Image: see text]
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spelling pubmed-93257962022-07-28 The Cologne-Mecklenburg-Vorpommern DMEK Donor Study (COMEDOS) — design and review of the influence of donor characteristics on Descemet membrane endothelial keratoplasty (DMEK) outcome Schrittenlocher, Silvia Matthaei, Mario Bachmann, Björn Cursiefen, Claus Graefes Arch Clin Exp Ophthalmol Review Article BACKGROUND: Posterior lamellar keratoplasty and especially Descemet membrane endothelial keratoplasty (DMEK) are gaining interest worldwide. Little is known about the influence of donor factors on DMEK outcome. Here we provide an overview of the existing peer-reviewed literature on this topic and present the design of the upcoming cooperation study COMEDOS (Cologne-Mecklenburg-Vorpommern DMEK Donor Study). METHODS: A literature search of PubMed and MEDLINE was conducted to retrieve articles published between September 2013 and May 2021. Seventeen peer-reviewed articles were selected. Design and concept of the prospective COMEDOS are outlined. RESULTS: Main interest parameters were the donor diabetes mellitus status, age, and lens status. There is a large heterogeneity regarding the sample size, study design, and investigated parameters. There seems to be a consensus that younger donors are associated with tighter rolls, a more difficult preparation, and unfolding setting. Diabetic donors seem to increase the risk of tissue tearing due to adherences and result more frequently in preparation failure. The COMEDOS aims not only to analyze the diabetes status of the donor, but also to correlate all donor systemic comorbidities and their ophthalmologic history to the DMEK clinical outcome. Furthermore, a correlation of Descemet membrane lamella preparation and surgery outcome is planned. CONCLUSION: Currently, there is a lack of knowledge regarding the effect and impact of donor tissue characteristics on DMEK outcome and complications. An in-depth investigation is planned by the upcoming COMEDOS to close this knowledge gap. [Image: see text] Springer Berlin Heidelberg 2022-03-16 2022 /pmc/articles/PMC9325796/ /pubmed/35294636 http://dx.doi.org/10.1007/s00417-022-05594-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Schrittenlocher, Silvia
Matthaei, Mario
Bachmann, Björn
Cursiefen, Claus
The Cologne-Mecklenburg-Vorpommern DMEK Donor Study (COMEDOS) — design and review of the influence of donor characteristics on Descemet membrane endothelial keratoplasty (DMEK) outcome
title The Cologne-Mecklenburg-Vorpommern DMEK Donor Study (COMEDOS) — design and review of the influence of donor characteristics on Descemet membrane endothelial keratoplasty (DMEK) outcome
title_full The Cologne-Mecklenburg-Vorpommern DMEK Donor Study (COMEDOS) — design and review of the influence of donor characteristics on Descemet membrane endothelial keratoplasty (DMEK) outcome
title_fullStr The Cologne-Mecklenburg-Vorpommern DMEK Donor Study (COMEDOS) — design and review of the influence of donor characteristics on Descemet membrane endothelial keratoplasty (DMEK) outcome
title_full_unstemmed The Cologne-Mecklenburg-Vorpommern DMEK Donor Study (COMEDOS) — design and review of the influence of donor characteristics on Descemet membrane endothelial keratoplasty (DMEK) outcome
title_short The Cologne-Mecklenburg-Vorpommern DMEK Donor Study (COMEDOS) — design and review of the influence of donor characteristics on Descemet membrane endothelial keratoplasty (DMEK) outcome
title_sort cologne-mecklenburg-vorpommern dmek donor study (comedos) — design and review of the influence of donor characteristics on descemet membrane endothelial keratoplasty (dmek) outcome
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325796/
https://www.ncbi.nlm.nih.gov/pubmed/35294636
http://dx.doi.org/10.1007/s00417-022-05594-w
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