Deletion of rifampicin-inactivating mono-ADP-ribosyl transferase gene of Mycobacterium smegmatis globally altered gene expression profile that favoured increase in ROS levels and thereby antibiotic resister generation

The physiological role of mono-ADP-ribosyl transferase (Arr) of Mycobacterium smegmatis, which inactivates rifampicin, remains unclear. An earlier study reported increased expression of arr during oxidative stress and DNA damage. This suggested a role for Arr in the oxidative status of the cell and...

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Detalles Bibliográficos
Autores principales: Swaminath, Sharmada, Pradhan, Atul, Nair, Rashmi Ravindran, Ajitkumar, Parthasarathi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325912/
https://www.ncbi.nlm.nih.gov/pubmed/35909599
http://dx.doi.org/10.1016/j.crmicr.2022.100142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9325912/
https://www.ncbi.nlm.nih.gov/pubmed/35909599
http://dx.doi.org/10.1016/j.crmicr.2022.100142

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