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Brain-Derived Neurotrophic Factor and Extracellular Vesicle-Derived miRNAs in an Italian Cohort of Individuals With Obesity: A Key to Explain the Link Between Depression and Atherothrombosis
BACKGROUND: Obesity and depression are intertwined diseases often associated with an increased risk of cardiovascular (CV) complications. Brain-Derived Neurotrophic Factor (BDNF), altered in the brain both of subjects with depression and obesity, provides a potential link between depression and thro...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326054/ https://www.ncbi.nlm.nih.gov/pubmed/35911513 http://dx.doi.org/10.3389/fcvm.2022.906483 |
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author | Amadio, Patrizia Macchi, Chiara Favero, Chiara Zarà, Marta Solazzo, Giulia Dioni, Laura Sandrini, Leonardo Vigna, Luisella Greco, Maria Francesca Buoli, Massimiliano Sirtori, Cesare R. Pesatori, Angela Cecilia Ieraci, Alessandro Ruscica, Massimiliano Barbieri, Silvia Stella Bollati, Valentina |
author_facet | Amadio, Patrizia Macchi, Chiara Favero, Chiara Zarà, Marta Solazzo, Giulia Dioni, Laura Sandrini, Leonardo Vigna, Luisella Greco, Maria Francesca Buoli, Massimiliano Sirtori, Cesare R. Pesatori, Angela Cecilia Ieraci, Alessandro Ruscica, Massimiliano Barbieri, Silvia Stella Bollati, Valentina |
author_sort | Amadio, Patrizia |
collection | PubMed |
description | BACKGROUND: Obesity and depression are intertwined diseases often associated with an increased risk of cardiovascular (CV) complications. Brain-Derived Neurotrophic Factor (BDNF), altered in the brain both of subjects with depression and obesity, provides a potential link between depression and thrombosis. Since the relationship among peripheral BDNF, depression and obesity is not well-defined, the aim of the present report has been to address this issue taking advantage of the contribution played by extracellular vesicle (EV)-derived miRNAs. RESEARCH PROCESS: Associations among circulating BDNF, depression and EV-derived miRNAs related to atherothrombosis have been evaluated in a large Italian cohort of obese individuals (n = 743), characterized by the Beck Depression Inventory (BDI-II) score. RESULTS: BDI-II was negatively associated with BDNF levels without a significant impact of the rs6265 BDNF polymorphism; this association was modified by raised levels of IFN-γ. BDNF levels were linked to an increase of 80 EV-derived miRNAs and a decrease of 59 miRNAs related to atherosclerosis and thrombosis. Network analysis identified at least 18 genes targeted by these miRNAs, 7 of which involved in depression and CV risk. The observation of a possible link among BDNF, depression, and miRNAs related to atherothrombosis and depression in obesity is novel and may lead to a wider use of BDNF as a CV risk biomarker in this specific subject group. |
format | Online Article Text |
id | pubmed-9326054 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93260542022-07-28 Brain-Derived Neurotrophic Factor and Extracellular Vesicle-Derived miRNAs in an Italian Cohort of Individuals With Obesity: A Key to Explain the Link Between Depression and Atherothrombosis Amadio, Patrizia Macchi, Chiara Favero, Chiara Zarà, Marta Solazzo, Giulia Dioni, Laura Sandrini, Leonardo Vigna, Luisella Greco, Maria Francesca Buoli, Massimiliano Sirtori, Cesare R. Pesatori, Angela Cecilia Ieraci, Alessandro Ruscica, Massimiliano Barbieri, Silvia Stella Bollati, Valentina Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: Obesity and depression are intertwined diseases often associated with an increased risk of cardiovascular (CV) complications. Brain-Derived Neurotrophic Factor (BDNF), altered in the brain both of subjects with depression and obesity, provides a potential link between depression and thrombosis. Since the relationship among peripheral BDNF, depression and obesity is not well-defined, the aim of the present report has been to address this issue taking advantage of the contribution played by extracellular vesicle (EV)-derived miRNAs. RESEARCH PROCESS: Associations among circulating BDNF, depression and EV-derived miRNAs related to atherothrombosis have been evaluated in a large Italian cohort of obese individuals (n = 743), characterized by the Beck Depression Inventory (BDI-II) score. RESULTS: BDI-II was negatively associated with BDNF levels without a significant impact of the rs6265 BDNF polymorphism; this association was modified by raised levels of IFN-γ. BDNF levels were linked to an increase of 80 EV-derived miRNAs and a decrease of 59 miRNAs related to atherosclerosis and thrombosis. Network analysis identified at least 18 genes targeted by these miRNAs, 7 of which involved in depression and CV risk. The observation of a possible link among BDNF, depression, and miRNAs related to atherothrombosis and depression in obesity is novel and may lead to a wider use of BDNF as a CV risk biomarker in this specific subject group. Frontiers Media S.A. 2022-07-13 /pmc/articles/PMC9326054/ /pubmed/35911513 http://dx.doi.org/10.3389/fcvm.2022.906483 Text en Copyright © 2022 Amadio, Macchi, Favero, Zarà, Solazzo, Dioni, Sandrini, Vigna, Greco, Buoli, Sirtori, Pesatori, Ieraci, Ruscica, Barbieri and Bollati. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Amadio, Patrizia Macchi, Chiara Favero, Chiara Zarà, Marta Solazzo, Giulia Dioni, Laura Sandrini, Leonardo Vigna, Luisella Greco, Maria Francesca Buoli, Massimiliano Sirtori, Cesare R. Pesatori, Angela Cecilia Ieraci, Alessandro Ruscica, Massimiliano Barbieri, Silvia Stella Bollati, Valentina Brain-Derived Neurotrophic Factor and Extracellular Vesicle-Derived miRNAs in an Italian Cohort of Individuals With Obesity: A Key to Explain the Link Between Depression and Atherothrombosis |
title | Brain-Derived Neurotrophic Factor and Extracellular Vesicle-Derived miRNAs in an Italian Cohort of Individuals With Obesity: A Key to Explain the Link Between Depression and Atherothrombosis |
title_full | Brain-Derived Neurotrophic Factor and Extracellular Vesicle-Derived miRNAs in an Italian Cohort of Individuals With Obesity: A Key to Explain the Link Between Depression and Atherothrombosis |
title_fullStr | Brain-Derived Neurotrophic Factor and Extracellular Vesicle-Derived miRNAs in an Italian Cohort of Individuals With Obesity: A Key to Explain the Link Between Depression and Atherothrombosis |
title_full_unstemmed | Brain-Derived Neurotrophic Factor and Extracellular Vesicle-Derived miRNAs in an Italian Cohort of Individuals With Obesity: A Key to Explain the Link Between Depression and Atherothrombosis |
title_short | Brain-Derived Neurotrophic Factor and Extracellular Vesicle-Derived miRNAs in an Italian Cohort of Individuals With Obesity: A Key to Explain the Link Between Depression and Atherothrombosis |
title_sort | brain-derived neurotrophic factor and extracellular vesicle-derived mirnas in an italian cohort of individuals with obesity: a key to explain the link between depression and atherothrombosis |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326054/ https://www.ncbi.nlm.nih.gov/pubmed/35911513 http://dx.doi.org/10.3389/fcvm.2022.906483 |
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