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Macrophages in Renal Injury, Repair, Fibrosis Following Acute Kidney Injury and Targeted Therapy
Acute kidney injury (AKI) is a renal disease with a high incidence and mortality. Currently, there are no targeted therapeutics for preventing and treating AKI. Macrophages, important players in mammalian immune response, are involved in the multiple pathological processes of AKI. They are dynamical...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326079/ https://www.ncbi.nlm.nih.gov/pubmed/35911736 http://dx.doi.org/10.3389/fimmu.2022.934299 |
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author | Chen, Hui Liu, Na Zhuang, Shougang |
author_facet | Chen, Hui Liu, Na Zhuang, Shougang |
author_sort | Chen, Hui |
collection | PubMed |
description | Acute kidney injury (AKI) is a renal disease with a high incidence and mortality. Currently, there are no targeted therapeutics for preventing and treating AKI. Macrophages, important players in mammalian immune response, are involved in the multiple pathological processes of AKI. They are dynamically activated and exhibit a diverse spectrum of functional phenotypes in the kidney after AKI. Targeting the mechanisms of macrophage activation significantly improves the outcomes of AKI in preclinical studies. In this review, we summarize the role of macrophages and the underlying mechanisms of macrophage activation during kidney injury, repair, regeneration, and fibrosis and provide strategies for macrophage-targeted therapies. |
format | Online Article Text |
id | pubmed-9326079 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93260792022-07-28 Macrophages in Renal Injury, Repair, Fibrosis Following Acute Kidney Injury and Targeted Therapy Chen, Hui Liu, Na Zhuang, Shougang Front Immunol Immunology Acute kidney injury (AKI) is a renal disease with a high incidence and mortality. Currently, there are no targeted therapeutics for preventing and treating AKI. Macrophages, important players in mammalian immune response, are involved in the multiple pathological processes of AKI. They are dynamically activated and exhibit a diverse spectrum of functional phenotypes in the kidney after AKI. Targeting the mechanisms of macrophage activation significantly improves the outcomes of AKI in preclinical studies. In this review, we summarize the role of macrophages and the underlying mechanisms of macrophage activation during kidney injury, repair, regeneration, and fibrosis and provide strategies for macrophage-targeted therapies. Frontiers Media S.A. 2022-07-13 /pmc/articles/PMC9326079/ /pubmed/35911736 http://dx.doi.org/10.3389/fimmu.2022.934299 Text en Copyright © 2022 Chen, Liu and Zhuang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Chen, Hui Liu, Na Zhuang, Shougang Macrophages in Renal Injury, Repair, Fibrosis Following Acute Kidney Injury and Targeted Therapy |
title | Macrophages in Renal Injury, Repair, Fibrosis Following Acute Kidney Injury and Targeted Therapy |
title_full | Macrophages in Renal Injury, Repair, Fibrosis Following Acute Kidney Injury and Targeted Therapy |
title_fullStr | Macrophages in Renal Injury, Repair, Fibrosis Following Acute Kidney Injury and Targeted Therapy |
title_full_unstemmed | Macrophages in Renal Injury, Repair, Fibrosis Following Acute Kidney Injury and Targeted Therapy |
title_short | Macrophages in Renal Injury, Repair, Fibrosis Following Acute Kidney Injury and Targeted Therapy |
title_sort | macrophages in renal injury, repair, fibrosis following acute kidney injury and targeted therapy |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326079/ https://www.ncbi.nlm.nih.gov/pubmed/35911736 http://dx.doi.org/10.3389/fimmu.2022.934299 |
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