A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions

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We report a live-attenuated SARS-CoV-2 vaccine candidate with (i) re-engineered viral transcription regulator sequences and (ii) deleted open-reading-frames (ORF) 3, 6, 7, and 8 (∆3678). The ∆3678 virus replicates about 7,500-fold lower than wild-type SARS-CoV-2 on primary human airway cultures, but...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Zhang, Xianwen, Liu, Jianying, Xia, Hongjie, Zou, Jing, Muruato, Antonio E., Periasamy, Sivakumar, Kurhade, Chaitanya, Plante, Jessica A., Bopp, Nathen E., Kalveram, Birte, Bukreyev, Alexander, Ren, Ping, Wang, Tian, Menachery, Vineet D., Plante, Kenneth S., Xie, Xuping, Weaver, Scott C., Shi, Pei-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326133/
https://www.ncbi.nlm.nih.gov/pubmed/35896528
http://dx.doi.org/10.1038/s41467-022-31930-z
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