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Estimation of serum immunoglobulin G and immunoglobulin A levels in oral submucous fibrosis patients

BACKGROUND: Oral submucous fibrosis (OSMF) is a disabling, chronic, insidious potentially malignant condition of the oral cavity seen predominantly in the Indian subcontinent. Due to the idiopathic nature and various immunological changes seen in some OSMF patients, it can be considered an autoimmun...

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Autores principales: Swami, Anand N., Kale, Lata M., Choudhary, Sneha H., Singh, Ashok Kumar, Aldhuwayhi, Sami D., Thakare, Amar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326200/
https://www.ncbi.nlm.nih.gov/pubmed/35911796
http://dx.doi.org/10.4103/njms.NJMS_238_20
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author Swami, Anand N.
Kale, Lata M.
Choudhary, Sneha H.
Singh, Ashok Kumar
Aldhuwayhi, Sami D.
Thakare, Amar
author_facet Swami, Anand N.
Kale, Lata M.
Choudhary, Sneha H.
Singh, Ashok Kumar
Aldhuwayhi, Sami D.
Thakare, Amar
author_sort Swami, Anand N.
collection PubMed
description BACKGROUND: Oral submucous fibrosis (OSMF) is a disabling, chronic, insidious potentially malignant condition of the oral cavity seen predominantly in the Indian subcontinent. Due to the idiopathic nature and various immunological changes seen in some OSMF patients, it can be considered an autoimmune disorder. Hyperimmunoglobulinemia is often seen with OSMF. AIM AND OBJECTIVES: (i) To estimate the serum immunoglobulin G (IgG) and immunoglobulin A (IgA) levels in OSMF patients; (ii) to correlate the serum IgG and IgA levels with age and gender of OSMF patients; (iii) to correlate the serum IgG and IgA levels with clinical stages of OSMF; (iv) to correlate the serum IgG and IgA levels with the content of the habit in OSMF patients. MATERIALS AND METHODS: Serum samples were collected from a total of 50 patients (25 OSMF cases and 25 controls) of both genders and IgG and IgA levels were estimated by NEPHELOMETRY. RESULTS: As compared to the control group, the mean serum IgG level was marginally increased among the OSMF patients and the mean serum IgA level was marginally decreased among the OSMF patients, but this was not statistically significant. Furthermore, there was only a weak correlation between serum immunoglobulins and content of the habit and no significant correlation was found between the serum IgG and IgA levels and age and sex of the OSMF patients. Serum IgG was increased and IgA was decreased with increasing stages of OSMF. CONCLUSION: The results of the present study suggested that there is an alteration in serum immunoglobulin levels in OSMF patients as compared to the control group.
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spelling pubmed-93262002022-07-28 Estimation of serum immunoglobulin G and immunoglobulin A levels in oral submucous fibrosis patients Swami, Anand N. Kale, Lata M. Choudhary, Sneha H. Singh, Ashok Kumar Aldhuwayhi, Sami D. Thakare, Amar Natl J Maxillofac Surg Original Article BACKGROUND: Oral submucous fibrosis (OSMF) is a disabling, chronic, insidious potentially malignant condition of the oral cavity seen predominantly in the Indian subcontinent. Due to the idiopathic nature and various immunological changes seen in some OSMF patients, it can be considered an autoimmune disorder. Hyperimmunoglobulinemia is often seen with OSMF. AIM AND OBJECTIVES: (i) To estimate the serum immunoglobulin G (IgG) and immunoglobulin A (IgA) levels in OSMF patients; (ii) to correlate the serum IgG and IgA levels with age and gender of OSMF patients; (iii) to correlate the serum IgG and IgA levels with clinical stages of OSMF; (iv) to correlate the serum IgG and IgA levels with the content of the habit in OSMF patients. MATERIALS AND METHODS: Serum samples were collected from a total of 50 patients (25 OSMF cases and 25 controls) of both genders and IgG and IgA levels were estimated by NEPHELOMETRY. RESULTS: As compared to the control group, the mean serum IgG level was marginally increased among the OSMF patients and the mean serum IgA level was marginally decreased among the OSMF patients, but this was not statistically significant. Furthermore, there was only a weak correlation between serum immunoglobulins and content of the habit and no significant correlation was found between the serum IgG and IgA levels and age and sex of the OSMF patients. Serum IgG was increased and IgA was decreased with increasing stages of OSMF. CONCLUSION: The results of the present study suggested that there is an alteration in serum immunoglobulin levels in OSMF patients as compared to the control group. Medknow Publications & Media Pvt Ltd 2022 2022-04-20 /pmc/articles/PMC9326200/ /pubmed/35911796 http://dx.doi.org/10.4103/njms.NJMS_238_20 Text en Copyright: © 2022 National Journal of Maxillofacial Surgery https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Swami, Anand N.
Kale, Lata M.
Choudhary, Sneha H.
Singh, Ashok Kumar
Aldhuwayhi, Sami D.
Thakare, Amar
Estimation of serum immunoglobulin G and immunoglobulin A levels in oral submucous fibrosis patients
title Estimation of serum immunoglobulin G and immunoglobulin A levels in oral submucous fibrosis patients
title_full Estimation of serum immunoglobulin G and immunoglobulin A levels in oral submucous fibrosis patients
title_fullStr Estimation of serum immunoglobulin G and immunoglobulin A levels in oral submucous fibrosis patients
title_full_unstemmed Estimation of serum immunoglobulin G and immunoglobulin A levels in oral submucous fibrosis patients
title_short Estimation of serum immunoglobulin G and immunoglobulin A levels in oral submucous fibrosis patients
title_sort estimation of serum immunoglobulin g and immunoglobulin a levels in oral submucous fibrosis patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326200/
https://www.ncbi.nlm.nih.gov/pubmed/35911796
http://dx.doi.org/10.4103/njms.NJMS_238_20
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