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Design and Synthesis of 1-O- and 6′-C-Modified Heparan Sulfate Trisaccharides as Human Endo-6-O-Sulfatase 1 Inhibitors

The extracellular human endo-6-O-sulfatases (Sulf-1 and Sulf-2) are responsible for the endolytic cleavage of the 6-sulfate groups from the internal D-glucosamine residues in the highly sulfated subdomains of heparan sulfate proteoglycans. A trisaccharide sulfate, IdoA2OS-GlcNS6S-IdoA2OS, was identi...

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Detalles Bibliográficos
Autores principales:	Tseng, Kuei-Yao, Tzeng, Zheng-Hao, Cheng, Ting-Jen Rachel, Liang, Pi-Hui, Hung, Shang-Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326219/ https://www.ncbi.nlm.nih.gov/pubmed/35910734 http://dx.doi.org/10.3389/fchem.2022.947475

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