Cargando…

Autism-Risk Gene necab2 Regulates Psychomotor and Social Behavior as a Neuronal Modulator of mGluR1 Signaling

BACKGROUND: De novo deletion of the neuronal calcium-binding protein 2 (NECAB2) locus is associated with idiopathic autism spectrum disorders (ASDs). The in vivo function of NECAB2 in the brain remains largely elusive. METHODS: We investigated the morphological and behavioral profiles of both necab2...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Zexu, Long, Han, Guo, Jianhua, Wang, Yiran, He, Kezhe, Tao, Chenchen, Li, Xiong, Jiang, Keji, Guo, Su, Pi, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326220/ https://www.ncbi.nlm.nih.gov/pubmed/35909444 http://dx.doi.org/10.3389/fnmol.2022.901682

Ejemplares similares

Two routes to autism phenotypes via mGluR5
Publicado: (2012)

NECAB1 and NECAB2 are Prevalent Calcium-Binding Proteins of CB(1)/CCK-Positive GABAergic Interneurons
por: Miczán, Vivien, et al.
Publicado: (2020)

Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications
por: Huang, Leyi, et al.
Publicado: (2023)

Group I mGluRs in Therapy and Diagnosis of Parkinson’s Disease: Focus on mGluR5 Subtype
por: Azam, Shofiul, et al.
Publicado: (2022)

Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density
por: Gross, Kellie S., et al.
Publicado: (2016)

mGluR5, CB1 and neuroprotection
por: Carvalho, Toniana G., et al.
Publicado: (2016)

The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency
por: Kammermeier, Paul J
Publicado: (2012)

The Changes in mGluR2 and mGluR7 Expression in Rat Medial Vestibular Nucleus and Flocculus Following Unilateral Labyrinthectomy
por: Zhou, Wen, et al.
Publicado: (2013)

Pretreatment with mGluR2 or mGluR3 Agonists Reduces Apoptosis Induced by Hypoxia-Ischemia in Neonatal Rat Brains
por: Bratek - Gerej, Ewelina, et al.
Publicado: (2021)

mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning
por: Harbers, Maria, et al.
Publicado: (2022)

Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression
por: Wood, Christian M., et al.
Publicado: (2018)

Glu-mGluR2/3-ERK Signaling Regulates Apoptosis of Hippocampal Neurons in Diabetic-Depression Model Rats
por: Liu, Zhuo, et al.
Publicado: (2019)

mGluR5 Ablation in Cortical Glutamatergic Neurons Increases Novelty-Induced Locomotion
por: Jew, Chris P., et al.
Publicado: (2013)

Regulation of GABA Equilibrium Potential by mGluRs in Rat Hippocampal CA1 Neurons
por: Yang, Bo, et al.
Publicado: (2015)

mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output
por: Valentinova, Kristina, et al.
Publicado: (2016)

mGluR-Dependent Synaptic Plasticity in Drug-Seeking
por: Bellone, Camilla, et al.
Publicado: (2012)

PET imaging of mGluR5 in Alzheimer’s disease
por: Mecca, Adam P., et al.
Publicado: (2020)

Disrupted mGluR5-Homer scaffolds mediate abnormal mGluR5 signaling, circuit function and behavior in a mouse model of Fragile X Syndrome
por: Ronesi, Jennifer A., et al.
Publicado: (2012)

Extinction-Dependent Alterations in Corticostriatal mGluR2/3 and mGluR7 Receptors following Chronic Methamphetamine Self-Administration in Rats
por: Schwendt, Marek, et al.
Publicado: (2012)

Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure
por: Alese, Oluwole Ojo, et al.
Publicado: (2019)

mGluR5-Antagonist Mediated Reversal of Elevated Stereotyped, Repetitive Behaviors in the VPA Model of Autism
por: Mehta, Mili V., et al.
Publicado: (2011)

High-Throughput Sequencing of mGluR Signaling Pathway Genes Reveals Enrichment of Rare Variants in Autism
por: Kelleher III, Raymond J., et al.
Publicado: (2012)

The Role of mGluR Copy Number Variation in Genetic and Environmental Forms of Syndromic Autism Spectrum Disorder
por: Wenger, Tara L., et al.
Publicado: (2016)

Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice
por: Edfawy, Mohamed, et al.
Publicado: (2019)

Target validation: Weak selectivity of LY341495 for mGluR2 over mGluR4 makes glutamate a less selective agonist
por: McCullock, Tyler W., et al.
Publicado: (2019)

Correction: Regulation of GABA Equilibrium Potential by mGluRs in Rat Hippocampal CA1 Neurons
por: Yang, Bo, et al.
Publicado: (2015)

Loss of mGluR5 in D1 Receptor-Expressing Neurons Improves Stress Coping
por: Zangrandi, Luca, et al.
Publicado: (2021)

Translational Concepts of mGluR5 in Synaptic Diseases of the Brain
por: Piers, Thomas M., et al.
Publicado: (2012)

Therapeutic potential of mGluR5 targeting in Alzheimer's disease
por: Kumar, Anil, et al.
Publicado: (2015)

mGluR5 hypofunction is integral to glutamatergic dysregulation in schizophrenia
por: Wang, Hoau-Yan, et al.
Publicado: (2018)

Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem
por: Goel, Nupur, et al.
Publicado: (2020)

Reduced mGluR5 Activity Modulates Mitochondrial Function
por: Gonzalez-Lozano, Miguel A., et al.
Publicado: (2021)

Selective Recruitment of Presynaptic and Postsynaptic Forms of mGluR-LTD
por: Sanderson, Thomas M., et al.
Publicado: (2022)

Role for Astrocytes in mGluR-Dependent LTD in the Neocortex and Hippocampus
por: Lalo, Ulyana, et al.
Publicado: (2022)

mGluR-dependent plasticity in rodent models of Alzheimer’s disease
por: Valdivia, Gonzalo, et al.
Publicado: (2023)

mGluR5 in amygdala modulates fear memory generalization
por: Xuan, Shou-Min, et al.
Publicado: (2023)

Loss of retinoid X receptor gamma subunit impairs group 1 mGluR mediated electrophysiological responses and group 1 mGluR dependent behaviors
por: Upreti, Chirag, et al.
Publicado: (2021)

Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro
por: Neyman, Sergey, et al.
Publicado: (2008)

Store-Operated Calcium Entry Is Required for mGluR-Dependent Long Term Depression in Cortical Neurons
por: González-Sánchez, Paloma, et al.
Publicado: (2017)

Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism
por: Wang, Xiaoming, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_q97oql1ultvafaodotr7a0o6rd