Cargando…

Opinion: PARP inhibitors in cancer—what do we still need to know?

PARP inhibitors (PARPi) have been demonstrated to exhibit profound anti-tumour activity in individuals whose cancers have a defect in the homologous recombination DNA repair pathway. Here, we describe the current consensus as to how PARPi work and how drug resistance to these agents emerges. We disc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wicks, Andrew J., Krastev, Dragomir B., Pettitt, Stephen J., Tutt, Andrew N. J., Lord, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326299/ https://www.ncbi.nlm.nih.gov/pubmed/35892198 http://dx.doi.org/10.1098/rsob.220118

Ejemplares similares

Antimicrobial Mouthwashes: An Overview of Mechanisms—What Do We Still Need to Know?
por: Brookes, Zoë, et al.
Publicado: (2023)

Secondary electron yield of surfaces: what we know and what we still need to know
por: Taborelli, M
Publicado: (2020)

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin
por: Krastev, Dragomir B., et al.
Publicado: (2022)

Phytochemical Molluscicides and Schistosomiasis: What We Know and What We Still Need to Learn
por: Augusto, Ronaldo de Carvalho, et al.
Publicado: (2018)

Biogenic Silver Nanoparticles: What We Know and What Do We Need to Know?
por: Rai, Mahendra, et al.
Publicado: (2021)

Equine Crofton Weed (Ageratina spp.) Pneumotoxicity: What Do We Know and What Do We Need to Know?
por: Shapter, Frances Marie, et al.
Publicado: (2023)

Environmental Forces that Shape Early Development: What We Know and Still Need to Know
por: Shankar, Kartik, et al.
Publicado: (2017)

A HUWE1 defect causes PARP inhibitor resistance by modulating the BRCA1-∆11q splice variant
por: Pettitt, Stephen J., et al.
Publicado: (2023)

Thoughts on NGS, alternative splicing and what we still need to know
por: Lynch, Kristen W.
Publicado: (2015)

The FIRE AND ICE Trial: What We Know, What We Can Still Learn, and What We Need to Address in the Future
por: Kuck, Karl‐Heinz, et al.
Publicado: (2018)

Goal-directed therapy: what we know and what we need to know
por: O’Neal, Jason B, et al.
Publicado: (2015)

Management of T1 Urothelial Carcinoma of the Bladder: What Do We Know and What Do We Need To Know?
por: Gershman, Boris, et al.
Publicado: (2015)

Cardiac surgery and the coronavirus disease 2019 pandemic: What we know, what we do not know, and what we need to do
por: Bakaeen, Faisal G., et al.
Publicado: (2020)

Paediatric schistosomiasis: What we know and what we need to know
por: Osakunor, Derick N. M., et al.
Publicado: (2018)

Quasicrystals: What do we know? What do we want to know? What can we know?
por: Steurer, Walter
Publicado: (2018)

Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency
por: Bajrami, Ilirjana, et al.
Publicado: (2021)

Publication ethics – What do we need to know?
por: Mills, Michael
Publicado: (2019)

Mediterranean Diet and NAFLD: What We Know and Questions That Still Need to Be Answered
por: Plaz Torres, Maria Corina, et al.
Publicado: (2019)

Evolutionary ecology of Chagas disease; what do we know and what do we need?
por: Flores‐Ferrer, Alheli, et al.
Publicado: (2017)

What do we know and when do we know it?
por: Nicholls, Anthony
Publicado: (2008)

Investigating emotions in Parkinson's disease: what we know and what we still don't know
por: Sotgiu, Igor, et al.
Publicado: (2013)

Presbyopia: What We Do Know and What We Do Not Know in 2022
por: Grzybowski, Andrzej, et al.
Publicado: (2023)

Acute kidney injury in critically ill newborns: What do we know? What do we need to learn?
por: Askenazi, David J., et al.
Publicado: (2009)

Cerebrospinal fluid circulation: What do we know and how do we know it?
por: Khasawneh, Ahmad H, et al.
Publicado: (2018)

What Do We Still Need to Know? Pressing Issues and Promising Directions in Research on Perfectionism and Nonsuicidal Self-injury
por: Janssen, William F., et al.
Publicado: (2022)

Monkeypox Outbreaks in Non-Endemic Countries: What Do We Know and What Do We Need?
por: Shamabadi, Ahmad, et al.
Publicado: (2022)

Membrane fission by dynamin: what we know and what we need to know
por: Antonny, Bruno, et al.
Publicado: (2016)

Epigenetics in Schistosomes: What We Know and What We Need Know
por: Liu, Weiwei
Publicado: (2016)

Portion Size: What We Know and What We Need to Know
por: Benton, David
Publicado: (2015)

Metabolic syndrome: what we know and what we need to know
por: Soares, Raquel
Publicado: (2020)

Vaginal Aging—What We Know and What We Do Not Know
por: Szymański, Jacek K., et al.
Publicado: (2021)

COVID-19 and cancer: do we really know what we think we know?
por: Robinson, Andrew G., et al.
Publicado: (2020)

Transmission of Ebola Viruses: What We Know and What We Do Not Know
por: Osterholm, Michael T., et al.
Publicado: (2015)

Neurogenic Stress Cardiomyopathy: What Do We Need to Know
por: Gopinath, Ramachandran, et al.
Publicado: (2018)

Veteran homelessness in Australia: What do we know? What has been done? What do we need to do?
por: Wallace, Duncan, et al.
Publicado: (2023)

Health Literacy and People with Intellectual Disabilities: What We Know, What We Do Not Know, and What We Need: A Theoretical Discourse
por: Geukes, Cornelia, et al.
Publicado: (2019)

Therapeutic Use of the Ketogenic Diet in Refractory Epilepsy: What We Know and What Still Needs to Be Learned
por: Zarnowska, Iwona Maria
Publicado: (2020)

What we still don't know about AIDS
por: Robertson, Miranda
Publicado: (2009)

First-Episode Psychosis care in Central Europe: What we have learned and what we still need to do
por: Réthelyi, J.
Publicado: (2022)

Exercise and Alcohol Consumption: What We Know, What We Need to Know, and Why it is Important
por: Leasure, J. Leigh, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ujglrcqrtao3ls0g1m52g0kh39