Lipoprotein-associated phospholipase A2 and carotid intima-media thickness in primary Sjögren syndrome
OBJECTIVES: This study aims to evaluate serum lipoprotein-associated phospholipase A2 (Lp-PLA2) level and carotid intima-media thickness in primary Sjögren syndrome (pSS) as an indicator of atherosclerosis. PATIENTS AND METHODS: Between July 2019 and July 2020, a total of 33 female pSS patients (mea...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Turkish League Against Rheumatism
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326383/ https://www.ncbi.nlm.nih.gov/pubmed/35949861 http://dx.doi.org/10.46497/ArchRheumatol.2022.8838 |
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author | Gültuna, Selcan Can Sandıkçı, Sevinç Kaplanoğlu, Hatice Aydın, Fevzi Nuri Özalp Ateş, Funda Seher |
author_facet | Gültuna, Selcan Can Sandıkçı, Sevinç Kaplanoğlu, Hatice Aydın, Fevzi Nuri Özalp Ateş, Funda Seher |
author_sort | Gültuna, Selcan |
collection | PubMed |
description | OBJECTIVES: This study aims to evaluate serum lipoprotein-associated phospholipase A2 (Lp-PLA2) level and carotid intima-media thickness in primary Sjögren syndrome (pSS) as an indicator of atherosclerosis. PATIENTS AND METHODS: Between July 2019 and July 2020, a total of 33 female pSS patients (mean age: 44.5±11.2 years; range, 23 to 60 years) and 37 female age- and sex-matched healthy individuals (mean age: 40.9±7.2 years; range, 25 to 54 years) were included. Carotid intima-media thickness and serum Lp-PLA2 levels were measured in the patient and control groups. RESULTS: The patients had a higher median serum Lp-PLA2 of 560 (range, 108 to 1,222) ng/mL vs. 328 (range, 0 to 1,280) ng/mL in the controls (p=0.024) and a similar mean intima-media thickness of carotid artery (0.64±0.14 mm vs. 0.62±0.15 mm, respectively; p=0.595). Serum Lp-PLA2 was positively correlated with platelet count (r=0.411, p=0.018) and negatively correlated with erythrocyte sedimentation rate (r=-0.409, p=0.018). The mean value of carotid intima-media thickness was positively correlated with disease duration (r=0.316, p=0.074) and was negatively correlated with the level of leucocyte (r=-0.458, p=0.007). CONCLUSION: Our study suggests that the patients of pSS have a potential risk of atherosclerotic cardiovascular disease, independent of traditional cardiovascular risk factors and disease severity. |
format | Online Article Text |
id | pubmed-9326383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Turkish League Against Rheumatism |
record_format | MEDLINE/PubMed |
spelling | pubmed-93263832022-08-09 Lipoprotein-associated phospholipase A2 and carotid intima-media thickness in primary Sjögren syndrome Gültuna, Selcan Can Sandıkçı, Sevinç Kaplanoğlu, Hatice Aydın, Fevzi Nuri Özalp Ateş, Funda Seher Arch Rheumatol Original Article OBJECTIVES: This study aims to evaluate serum lipoprotein-associated phospholipase A2 (Lp-PLA2) level and carotid intima-media thickness in primary Sjögren syndrome (pSS) as an indicator of atherosclerosis. PATIENTS AND METHODS: Between July 2019 and July 2020, a total of 33 female pSS patients (mean age: 44.5±11.2 years; range, 23 to 60 years) and 37 female age- and sex-matched healthy individuals (mean age: 40.9±7.2 years; range, 25 to 54 years) were included. Carotid intima-media thickness and serum Lp-PLA2 levels were measured in the patient and control groups. RESULTS: The patients had a higher median serum Lp-PLA2 of 560 (range, 108 to 1,222) ng/mL vs. 328 (range, 0 to 1,280) ng/mL in the controls (p=0.024) and a similar mean intima-media thickness of carotid artery (0.64±0.14 mm vs. 0.62±0.15 mm, respectively; p=0.595). Serum Lp-PLA2 was positively correlated with platelet count (r=0.411, p=0.018) and negatively correlated with erythrocyte sedimentation rate (r=-0.409, p=0.018). The mean value of carotid intima-media thickness was positively correlated with disease duration (r=0.316, p=0.074) and was negatively correlated with the level of leucocyte (r=-0.458, p=0.007). CONCLUSION: Our study suggests that the patients of pSS have a potential risk of atherosclerotic cardiovascular disease, independent of traditional cardiovascular risk factors and disease severity. Turkish League Against Rheumatism 2021-10-16 /pmc/articles/PMC9326383/ /pubmed/35949861 http://dx.doi.org/10.46497/ArchRheumatol.2022.8838 Text en Copyright © 2022, Turkish League Against Rheumatism https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Article Gültuna, Selcan Can Sandıkçı, Sevinç Kaplanoğlu, Hatice Aydın, Fevzi Nuri Özalp Ateş, Funda Seher Lipoprotein-associated phospholipase A2 and carotid intima-media thickness in primary Sjögren syndrome |
title | Lipoprotein-associated phospholipase A2 and carotid intima-media thickness in primary Sjögren syndrome |
title_full | Lipoprotein-associated phospholipase A2 and carotid intima-media thickness in primary Sjögren syndrome |
title_fullStr | Lipoprotein-associated phospholipase A2 and carotid intima-media thickness in primary Sjögren syndrome |
title_full_unstemmed | Lipoprotein-associated phospholipase A2 and carotid intima-media thickness in primary Sjögren syndrome |
title_short | Lipoprotein-associated phospholipase A2 and carotid intima-media thickness in primary Sjögren syndrome |
title_sort | lipoprotein-associated phospholipase a2 and carotid intima-media thickness in primary sjögren syndrome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326383/ https://www.ncbi.nlm.nih.gov/pubmed/35949861 http://dx.doi.org/10.46497/ArchRheumatol.2022.8838 |
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