Lipoprotein-associated phospholipase A2 and carotid intima-media thickness in primary Sjögren syndrome

OBJECTIVES: This study aims to evaluate serum lipoprotein-associated phospholipase A2 (Lp-PLA2) level and carotid intima-media thickness in primary Sjögren syndrome (pSS) as an indicator of atherosclerosis. PATIENTS AND METHODS: Between July 2019 and July 2020, a total of 33 female pSS patients (mea...

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Autores principales: Gültuna, Selcan, Can Sandıkçı, Sevinç, Kaplanoğlu, Hatice, Aydın, Fevzi Nuri, Özalp Ateş, Funda Seher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Turkish League Against Rheumatism 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326383/
https://www.ncbi.nlm.nih.gov/pubmed/35949861
http://dx.doi.org/10.46497/ArchRheumatol.2022.8838
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author Gültuna, Selcan
Can Sandıkçı, Sevinç
Kaplanoğlu, Hatice
Aydın, Fevzi Nuri
Özalp Ateş, Funda Seher
author_facet Gültuna, Selcan
Can Sandıkçı, Sevinç
Kaplanoğlu, Hatice
Aydın, Fevzi Nuri
Özalp Ateş, Funda Seher
author_sort Gültuna, Selcan
collection PubMed
description OBJECTIVES: This study aims to evaluate serum lipoprotein-associated phospholipase A2 (Lp-PLA2) level and carotid intima-media thickness in primary Sjögren syndrome (pSS) as an indicator of atherosclerosis. PATIENTS AND METHODS: Between July 2019 and July 2020, a total of 33 female pSS patients (mean age: 44.5±11.2 years; range, 23 to 60 years) and 37 female age- and sex-matched healthy individuals (mean age: 40.9±7.2 years; range, 25 to 54 years) were included. Carotid intima-media thickness and serum Lp-PLA2 levels were measured in the patient and control groups. RESULTS: The patients had a higher median serum Lp-PLA2 of 560 (range, 108 to 1,222) ng/mL vs. 328 (range, 0 to 1,280) ng/mL in the controls (p=0.024) and a similar mean intima-media thickness of carotid artery (0.64±0.14 mm vs. 0.62±0.15 mm, respectively; p=0.595). Serum Lp-PLA2 was positively correlated with platelet count (r=0.411, p=0.018) and negatively correlated with erythrocyte sedimentation rate (r=-0.409, p=0.018). The mean value of carotid intima-media thickness was positively correlated with disease duration (r=0.316, p=0.074) and was negatively correlated with the level of leucocyte (r=-0.458, p=0.007). CONCLUSION: Our study suggests that the patients of pSS have a potential risk of atherosclerotic cardiovascular disease, independent of traditional cardiovascular risk factors and disease severity.
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spelling pubmed-93263832022-08-09 Lipoprotein-associated phospholipase A2 and carotid intima-media thickness in primary Sjögren syndrome Gültuna, Selcan Can Sandıkçı, Sevinç Kaplanoğlu, Hatice Aydın, Fevzi Nuri Özalp Ateş, Funda Seher Arch Rheumatol Original Article OBJECTIVES: This study aims to evaluate serum lipoprotein-associated phospholipase A2 (Lp-PLA2) level and carotid intima-media thickness in primary Sjögren syndrome (pSS) as an indicator of atherosclerosis. PATIENTS AND METHODS: Between July 2019 and July 2020, a total of 33 female pSS patients (mean age: 44.5±11.2 years; range, 23 to 60 years) and 37 female age- and sex-matched healthy individuals (mean age: 40.9±7.2 years; range, 25 to 54 years) were included. Carotid intima-media thickness and serum Lp-PLA2 levels were measured in the patient and control groups. RESULTS: The patients had a higher median serum Lp-PLA2 of 560 (range, 108 to 1,222) ng/mL vs. 328 (range, 0 to 1,280) ng/mL in the controls (p=0.024) and a similar mean intima-media thickness of carotid artery (0.64±0.14 mm vs. 0.62±0.15 mm, respectively; p=0.595). Serum Lp-PLA2 was positively correlated with platelet count (r=0.411, p=0.018) and negatively correlated with erythrocyte sedimentation rate (r=-0.409, p=0.018). The mean value of carotid intima-media thickness was positively correlated with disease duration (r=0.316, p=0.074) and was negatively correlated with the level of leucocyte (r=-0.458, p=0.007). CONCLUSION: Our study suggests that the patients of pSS have a potential risk of atherosclerotic cardiovascular disease, independent of traditional cardiovascular risk factors and disease severity. Turkish League Against Rheumatism 2021-10-16 /pmc/articles/PMC9326383/ /pubmed/35949861 http://dx.doi.org/10.46497/ArchRheumatol.2022.8838 Text en Copyright © 2022, Turkish League Against Rheumatism https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Article
Gültuna, Selcan
Can Sandıkçı, Sevinç
Kaplanoğlu, Hatice
Aydın, Fevzi Nuri
Özalp Ateş, Funda Seher
Lipoprotein-associated phospholipase A2 and carotid intima-media thickness in primary Sjögren syndrome
title Lipoprotein-associated phospholipase A2 and carotid intima-media thickness in primary Sjögren syndrome
title_full Lipoprotein-associated phospholipase A2 and carotid intima-media thickness in primary Sjögren syndrome
title_fullStr Lipoprotein-associated phospholipase A2 and carotid intima-media thickness in primary Sjögren syndrome
title_full_unstemmed Lipoprotein-associated phospholipase A2 and carotid intima-media thickness in primary Sjögren syndrome
title_short Lipoprotein-associated phospholipase A2 and carotid intima-media thickness in primary Sjögren syndrome
title_sort lipoprotein-associated phospholipase a2 and carotid intima-media thickness in primary sjögren syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326383/
https://www.ncbi.nlm.nih.gov/pubmed/35949861
http://dx.doi.org/10.46497/ArchRheumatol.2022.8838
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