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Increased Insulin Resistance in Hepatitis-C Infection—Association with Altered Hepatic Function Testing

Introduction: Hepatitis C virus (HCV) infection is a serious global public health problem. It is estimated that 2% to 3% of the world’s population is infected with the virus. It was found that chronic hepatitis C is an independent predictor of the development of type 2 diabetes mellitus. Infection w...

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Autores principales: Mishra, Praveen Raman, Bharti, Akash, Arora, Ridhi, Mir, Irfan Ahmad, Punia, V. P. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326586/
https://www.ncbi.nlm.nih.gov/pubmed/35893594
http://dx.doi.org/10.3390/pathophysiology29030024
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author Mishra, Praveen Raman
Bharti, Akash
Arora, Ridhi
Mir, Irfan Ahmad
Punia, V. P. S.
author_facet Mishra, Praveen Raman
Bharti, Akash
Arora, Ridhi
Mir, Irfan Ahmad
Punia, V. P. S.
author_sort Mishra, Praveen Raman
collection PubMed
description Introduction: Hepatitis C virus (HCV) infection is a serious global public health problem. It is estimated that 2% to 3% of the world’s population is infected with the virus. It was found that chronic hepatitis C is an independent predictor of the development of type 2 diabetes mellitus. Infection with HCV or the inflammatory response to HCV infection likely contributes to the development of insulin resistance (IR), which increases the risk of developing type 2 diabetes in the long term. This study aimed to assess the insulin resistance in hepatitis C and its correlation with various metabolic parameters. Materials and Methods: This cross-sectional observational study was conducted at a tertiary care hospital in North India in the Department of Internal Medicine with hepatitis C-positive patients attending an out-patient or in-patient department. We took a total of 100 patients aged > 18 years and divided them into two groups: Group A with hepatitis C (cases) and Group B without hepatitis C (controls). There were a total of 50 hepatitis C patients and 50 patients without hepatitis C. Results: A total of 100 patients were included in the present study after obtaining informed consent. There was a significantly higher level of serum ferritin and insulin in group A patients than group B patients. There was a positive correlation of insulin resistance with the serum insulin, ferritin levels, cholesterol, LDL and triglyceride level and a negative correlation with the serum HDL level. The incidence of insulin resistance was positively correlated with changes in fibrosis in the liver due to the hepatitis C infection. Conclusions: From our study, we found that there is an increased incidence of insulin resistance in the patients with hepatitis-C infection, and insulin resistance is associated with the presence of altered hepatic function test results.
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spelling pubmed-93265862022-07-28 Increased Insulin Resistance in Hepatitis-C Infection—Association with Altered Hepatic Function Testing Mishra, Praveen Raman Bharti, Akash Arora, Ridhi Mir, Irfan Ahmad Punia, V. P. S. Pathophysiology Article Introduction: Hepatitis C virus (HCV) infection is a serious global public health problem. It is estimated that 2% to 3% of the world’s population is infected with the virus. It was found that chronic hepatitis C is an independent predictor of the development of type 2 diabetes mellitus. Infection with HCV or the inflammatory response to HCV infection likely contributes to the development of insulin resistance (IR), which increases the risk of developing type 2 diabetes in the long term. This study aimed to assess the insulin resistance in hepatitis C and its correlation with various metabolic parameters. Materials and Methods: This cross-sectional observational study was conducted at a tertiary care hospital in North India in the Department of Internal Medicine with hepatitis C-positive patients attending an out-patient or in-patient department. We took a total of 100 patients aged > 18 years and divided them into two groups: Group A with hepatitis C (cases) and Group B without hepatitis C (controls). There were a total of 50 hepatitis C patients and 50 patients without hepatitis C. Results: A total of 100 patients were included in the present study after obtaining informed consent. There was a significantly higher level of serum ferritin and insulin in group A patients than group B patients. There was a positive correlation of insulin resistance with the serum insulin, ferritin levels, cholesterol, LDL and triglyceride level and a negative correlation with the serum HDL level. The incidence of insulin resistance was positively correlated with changes in fibrosis in the liver due to the hepatitis C infection. Conclusions: From our study, we found that there is an increased incidence of insulin resistance in the patients with hepatitis-C infection, and insulin resistance is associated with the presence of altered hepatic function test results. MDPI 2022-06-21 /pmc/articles/PMC9326586/ /pubmed/35893594 http://dx.doi.org/10.3390/pathophysiology29030024 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mishra, Praveen Raman
Bharti, Akash
Arora, Ridhi
Mir, Irfan Ahmad
Punia, V. P. S.
Increased Insulin Resistance in Hepatitis-C Infection—Association with Altered Hepatic Function Testing
title Increased Insulin Resistance in Hepatitis-C Infection—Association with Altered Hepatic Function Testing
title_full Increased Insulin Resistance in Hepatitis-C Infection—Association with Altered Hepatic Function Testing
title_fullStr Increased Insulin Resistance in Hepatitis-C Infection—Association with Altered Hepatic Function Testing
title_full_unstemmed Increased Insulin Resistance in Hepatitis-C Infection—Association with Altered Hepatic Function Testing
title_short Increased Insulin Resistance in Hepatitis-C Infection—Association with Altered Hepatic Function Testing
title_sort increased insulin resistance in hepatitis-c infection—association with altered hepatic function testing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326586/
https://www.ncbi.nlm.nih.gov/pubmed/35893594
http://dx.doi.org/10.3390/pathophysiology29030024
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