Cargando…

Endocrine-Disrupting Effects of Bisphenol A on the Cardiovascular System: A Review

Currently, the plastic monomer and plasticizer bisphenol A (BPA) is one of the most widely used chemicals. BPA is present in polycarbonate plastics and epoxy resins, commonly used in food storage and industrial or medical products. However, the use of this synthetic compound is a growing concern, as...

Descripción completa

Detalles Bibliográficos
Autores principales: Fonseca, Maria Inês, Lorigo, Margarida, Cairrao, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326625/
https://www.ncbi.nlm.nih.gov/pubmed/35893265
http://dx.doi.org/10.3390/jox12030015
_version_ 1784757330967003136
author Fonseca, Maria Inês
Lorigo, Margarida
Cairrao, Elisa
author_facet Fonseca, Maria Inês
Lorigo, Margarida
Cairrao, Elisa
author_sort Fonseca, Maria Inês
collection PubMed
description Currently, the plastic monomer and plasticizer bisphenol A (BPA) is one of the most widely used chemicals. BPA is present in polycarbonate plastics and epoxy resins, commonly used in food storage and industrial or medical products. However, the use of this synthetic compound is a growing concern, as BPA is an endocrine-disrupting compound and can bind mainly to estrogen receptors, interfering with different functions at the cardiovascular level. Several studies have investigated the disruptive effects of BPA; however, its cardiotoxicity remains unclear. Therefore, this review’s purpose is to address the most recent studies on the implications of BPA on the cardiovascular system. Our findings suggest that BPA impairs cardiac excitability through intracellular mechanisms, involving the inhibition of the main ion channels, changes in Ca(2+) handling, the induction of oxidative stress, and epigenetic modifications. Our data support that BPA exposure increases the risk of developing cardiovascular diseases (CVDs) including atherosclerosis and its risk factors such as hypertension and diabetes. Furthermore, BPA exposure is also particularly harmful in pregnancy, promoting the development of hypertensive disorders during pregnancy. In summary, BPA exposure compromises human health, promoting the development and progression of CVDs and risk factors. Further studies are needed to clarify the human health effects of BPA-induced cardiotoxicity.
format Online
Article
Text
id pubmed-9326625
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93266252022-07-28 Endocrine-Disrupting Effects of Bisphenol A on the Cardiovascular System: A Review Fonseca, Maria Inês Lorigo, Margarida Cairrao, Elisa J Xenobiot Review Currently, the plastic monomer and plasticizer bisphenol A (BPA) is one of the most widely used chemicals. BPA is present in polycarbonate plastics and epoxy resins, commonly used in food storage and industrial or medical products. However, the use of this synthetic compound is a growing concern, as BPA is an endocrine-disrupting compound and can bind mainly to estrogen receptors, interfering with different functions at the cardiovascular level. Several studies have investigated the disruptive effects of BPA; however, its cardiotoxicity remains unclear. Therefore, this review’s purpose is to address the most recent studies on the implications of BPA on the cardiovascular system. Our findings suggest that BPA impairs cardiac excitability through intracellular mechanisms, involving the inhibition of the main ion channels, changes in Ca(2+) handling, the induction of oxidative stress, and epigenetic modifications. Our data support that BPA exposure increases the risk of developing cardiovascular diseases (CVDs) including atherosclerosis and its risk factors such as hypertension and diabetes. Furthermore, BPA exposure is also particularly harmful in pregnancy, promoting the development of hypertensive disorders during pregnancy. In summary, BPA exposure compromises human health, promoting the development and progression of CVDs and risk factors. Further studies are needed to clarify the human health effects of BPA-induced cardiotoxicity. MDPI 2022-07-13 /pmc/articles/PMC9326625/ /pubmed/35893265 http://dx.doi.org/10.3390/jox12030015 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fonseca, Maria Inês
Lorigo, Margarida
Cairrao, Elisa
Endocrine-Disrupting Effects of Bisphenol A on the Cardiovascular System: A Review
title Endocrine-Disrupting Effects of Bisphenol A on the Cardiovascular System: A Review
title_full Endocrine-Disrupting Effects of Bisphenol A on the Cardiovascular System: A Review
title_fullStr Endocrine-Disrupting Effects of Bisphenol A on the Cardiovascular System: A Review
title_full_unstemmed Endocrine-Disrupting Effects of Bisphenol A on the Cardiovascular System: A Review
title_short Endocrine-Disrupting Effects of Bisphenol A on the Cardiovascular System: A Review
title_sort endocrine-disrupting effects of bisphenol a on the cardiovascular system: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9326625/
https://www.ncbi.nlm.nih.gov/pubmed/35893265
http://dx.doi.org/10.3390/jox12030015
work_keys_str_mv AT fonsecamariaines endocrinedisruptingeffectsofbisphenolaonthecardiovascularsystemareview
AT lorigomargarida endocrinedisruptingeffectsofbisphenolaonthecardiovascularsystemareview
AT cairraoelisa endocrinedisruptingeffectsofbisphenolaonthecardiovascularsystemareview